Roger Dmochowski led the peer-review process as the Associate Editor responsible for the paper.
Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder
Version of Record online: 22 AUG 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 1, pages 101–105, January 2014
How to Cite
Chung, K.-H., Liu, S.-P., Lin, H.-C. and Chung, S.-D. (2014), Bladder pain syndrome/interstitial cystitis is associated with anxiety disorder. Neurourol. Urodyn., 33: 101–105. doi: 10.1002/nau.22382
Conflict of interest: none.
- Issue online: 11 DEC 2013
- Version of Record online: 22 AUG 2013
- Manuscript Accepted: 17 JAN 2013
- Manuscript Received: 25 DEC 2012
- bladder pain syndrome/interstitial cystitis;
- interstitial cystitis;
- rheumatoid arthritis
Recent research demonstrated that bladder pain syndrome/interstitial cystitis (BPS/IC) is associated with many coexisting physical and psychiatric conditions. In this study, we explored the potential association between anxiety disorder (AD) and BPS/IC using a case–controlled population-based approach in Taiwan.
Data on the sampled subjects analyzed in this study were retrieved from the Longitudinal Health Insurance Database 2000. Our study included 396 female cases with BPS/IC and 1,980 randomly selected female controls. We excluded subjects who had a history of major psychosis (except AD) or a substance-related disorder. A conditional logistic regression was performed to calculate the odds ratio (OR) for the association between a previous diagnosis of AD and IC/BPS.
Of the 2,376 sampled subjects, 136 (5.72%) had received an AD diagnosis. AD was found in 64 (16.16%) cases and in 72 (3.64%) controls (P < 0.001). The conditional logistic regression analysis (conditioned on age group and the index year) suggested that compared to controls, the OR for prior AD among cases was 4.59 (95% confidence interval (CI) = 2.32–9.08, P < 0.001). After adjusting for chronic pelvic pain, irritable bowel syndrome, fibromyalgia, migraines, sicca syndrome, allergies, asthma, and an overactive bladder, the OR for prior AD among cases was 4.37 (95% CI = 2.16–8.85, P < 0.001) compared to the controls.
There was an association between AD and BPS/IC, even after taking demographic characteristics, medical co-morbidities, and substance-related disorders into consideration. Results of this study should alert clinicians to evaluate and monitor the presence of BPS/IC in patients with AD. Neurourol. Urodynam. 33:101–105, 2014. © 2013 Wiley Periodicals, Inc.