Roger Dmochowski led the peer-review process as the Associate Editor responsible for the paper.
Evidence Based Medicine
Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: A population-based matched-cohort study
Article first published online: 28 MAR 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 3, pages 278–282, March 2014
How to Cite
Chung, S.-D., Lin, C.-C., Liu, S.-P. and Lin, H.-C. (2014), Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: A population-based matched-cohort study. Neurourol. Urodyn., 33: 278–282. doi: 10.1002/nau.22401
Shiu-Dong Chung and Ching-Chun Lin have equal contributions to this study.
The authors have no proprietary or commercial interest in any materials mentioned in this article.
Conflict of interest: none.
- Issue published online: 15 MAR 2014
- Article first published online: 28 MAR 2013
- Manuscript Accepted: 25 FEB 2013
- Manuscript Received: 29 JAN 2013
- interstitial cystitis;
- obstructive sleep apnea
Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3-year follow-up in Taiwan using a population-based dataset.
This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed-up each sampled subject (n = 32,340) for a 3-year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA.
Incidences of BPS/IC during the 3-year follow-up period were 13.61 (95% confidence interval [CI] = 7.37–23.13) and 3.60 (95% CI = 2.06–4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95% CI = 1.81–7.62, P < 0.001) that of comparison subjects.
This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population. Neurourol. Urodynam. 33:278–282, 2014. © 2013 Wiley Periodicals, Inc.