Dirk De Ridder led the peer-review process as the Associate Editor responsible for the paper.
The relationship between cerebral white matter hyperintensities and lower urinary tract function in a population based, geriatric cohort
Article first published online: 14 JUN 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 4, pages 431–436, April 2014
How to Cite
Wehrberger, C., Jungwirth, S., Fischer, P., Tragl, K.-H., Krampla, W., Marlies, W. and Madersbacher, S. (2014), The relationship between cerebral white matter hyperintensities and lower urinary tract function in a population based, geriatric cohort. Neurourol. Urodyn., 33: 431–436. doi: 10.1002/nau.22419
Conflict of interest: none.
- Issue published online: 3 APR 2014
- Article first published online: 14 JUN 2013
- Manuscript Accepted: 5 APR 2013
- Manuscript Received: 25 JAN 2013
- over active bladder;
- white matter hyperintensities;
White matter hyperintensities (WHM) in cerebral MRI-scan have been suspected to be involved in the pathogenesis for geriatric LUTS. Aim of this study was to investigate this association in a geriatric cohort.
Materials and Methods
The VITA-study is a prospective, population-based study initiated 2000/2001. All inhabitants of a well-defined area in Vienna aged 75 years were recruited and underwent detailed regular visits including cerebral MRI-scans. Subcortical and periventricular WMHs were classified according to the Fazekas-classification. In 2010, all subjects alive were contacted to complete the Bristol LUTS questionnaire.
Two hundred seventeen participants (75 men, 142 women), all 85 years old, entered this analysis. Urgency, frequency, and nocturia was present in 39 (50.7%), 53 (52%), and 55 (73.3%) men and 79 (55.6%), 81 (78.2%), and 68 (47.9%) women, respectively. OAB symptoms were seen in 55% of women and 50% of men. At baseline, WMH were present in 68.2% and this percentage increased to 85.7% at the most recent follow-up. Several symptoms were more prevalent in participants without WMH as compared to those with WMH, (urgency: 71% vs. 53%, P = 0.06, nocturia: 77% vs. 53%, P = 0.01: OAB-symptoms: 71% vs. 51%, P = 0.05. Only frequency was more prevalent in participants with WMH (77% vs. 68%, P = 0.27). In general, sub-categorization into periventricular and subcortical WMH confirmed these data. Furthermore the amount of WMH-burden did not correlate to LUT dysfunction.
This study failed to demonstrate a clear association between several aspects of LUTS and WMH in a rather healthy, population-based 85-year-old cohort. Neurourol. Urodynam. 33:431–436, 2014. © 2013 Wiley Periodicals, Inc.