Conflict of interest: None.
Frontiers in Urology
Central nervous targets for the treatment of bladder dysfunction
Article first published online: 5 JUL 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 1, pages 59–66, January 2014
How to Cite
Yoshimura, N., Miyazato, M., Kitta, T. and Yoshikawa, S. (2014), Central nervous targets for the treatment of bladder dysfunction. Neurourol. Urodyn., 33: 59–66. doi: 10.1002/nau.22455
Karl-Erik Andersson led the peer-review process as the Associate Editor responsible for the article.
- Issue published online: 11 DEC 2013
- Article first published online: 5 JUL 2013
- Manuscript Accepted: 5 JUN 2013
- Manuscript Received: 14 FEB 2013
- National Institutes of Health. Grant Numbers: DK057267, DK088836
- Department of Defense. Grant Numbers: W81XWH-11-1-0763, W81XWH-12-1-0565
- Paralyzed Veterans of America. Grant Number: 2793
- bladder overactivity;
- central nervous system;
- gene therapy;
The functions of the lower urinary tract, to store and periodically release urine, are dependent on the activity of smooth and striated muscles in the urinary bladder, urethra, and external urethral sphincter. This activity is in turn controlled by neural circuits in the brain, spinal cord, and peripheral ganglia.
This paper will review recent advances in our understanding of the pathophysiology of voiding disorders, especially focusing on the central nervous system.
Various neurotransmitters, including acetylcholine, norepinephrine, dopamine, serotonin, excitatory and inhibitory amino acids, adenosine triphosphate, nitric oxide, and neuropeptides, have been implicated in the neural regulation of the lower urinary tract.
Injuries or diseases of the nervous system, as well as drugs and disorders of the peripheral organs, can produce voiding dysfunctions such as urinary frequency, urgency, or incontinence.
We discuss the potential targets in the central nervous system and new modalities for the treatment of voiding dysfunction. Neurourol. Urodynam. 33:59–66, 2014. © 2013 Wiley Periodicals, Inc.