Christopher Chapple led the peer-review process as the Associate Editor responsible for the paper.
Review and Evidence Base
Oestrogens and overactive bladder
Article first published online: 19 JUL 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 7, pages 1086–1091, September 2014
How to Cite
Robinson, D., Cardozo, L., Milsom, I., Pons, M. E., Kirby, M., Koelbl, H. and Vierhout, M. (2014), Oestrogens and overactive bladder. Neurourol. Urodyn., 33: 1086–1091. doi: 10.1002/nau.22464
Conflict of Interest: Yes, I have acted as a consultant for Astellas, Pfizer, Allergan, and Ferring. I am a researcher for Astellas, Pfizer, and Allergan with kind regards, Jen.
- Issue published online: 11 AUG 2014
- Article first published online: 19 JUL 2013
- Manuscript Accepted: 13 JUN 2013
- Manuscript Received: 24 DEC 2012
- hormone replacement therapy;
- overactive bladder
Estrogens are known to have a major role in the function of the lower urinary tract although the role of exogenous estrogen replacement therapy in the management of women with lower urinary tract dysfunction remains controversial. Whilst for many years systemic and vaginal estrogen therapy was felt to be beneficial in the treatment of lower urinary and genital tract symptoms this evidence has recently been challenged by large epidemiological studies investigating the use of systemic hormone replacement therapy. Consequently the role of estrogen in the management of postmenopausal women with Overactive Bladder (OAB) remains uncertain. In addition the evidence base regarding the use of exogenous estrogen therapy has changed significantly over the last decade and has led to a major changes in current clinical practice. The aim of this article is to review the evidence for the role of estrogen therapy in the management of OAB focusing on current knowledge with regard to both systemic and local estrogen therapy as well as investigating the emerging role of combination therapy with antimuscarinic agents. Neurourol. Urodynam. 33:1086–1091, 2014. © 2013 Wiley Periodicals, Inc.