Karl-Erik Andersson led the peer-review process as the Associate Editor responsible for the paper.
Review and Evidence Base
Prostatic α1-adrenoceptors: New concepts of function, regulation, and intracellular signaling
Article first published online: 22 AUG 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 33, Issue 7, pages 1074–1085, September 2014
How to Cite
Hennenberg, M., Stief, C. G. and Gratzke, C. (2014), Prostatic α1-adrenoceptors: New concepts of function, regulation, and intracellular signaling. Neurourol. Urodyn., 33: 1074–1085. doi: 10.1002/nau.22467
Conflict of interest: none.
- Issue published online: 11 AUG 2014
- Article first published online: 22 AUG 2013
- Manuscript Accepted: 27 JUN 2013
- Manuscript Received: 5 APR 2013
- benign prostatic hyperplasia (BPH);
- benign prostatic syndrome (BPS);
- lower urinary tract symptoms (LUTS);
- smooth muscle;
Prostatic α1-adrenoceptors are known to be involved in the pathophysiology of lower urinary tract symptoms (LUTS) in patients with benign prostate obstruction (BPO). It is widely accepted that enhanced α1-adrenergic smooth muscle contraction can contribute to bladder outlet obstruction; α1-adrenoceptor antagonists still represent a gold standard in the treatment of LUTS. Accordingly, expression and function of α1-adrenoceptors in the prostate have attracted large attention over the last three decades. However, recent preclinical studies have challenged our understanding of prostatic α1-adrenoceptors. In the current review article, we summarize “modern” concepts of prostatic α1-adrenoceptors which include novel intracellular mediators of contraction as well as non-contractile signaling and post-translational receptor regulation. Configuration of α1-adrenoceptors with binding partners may determine its function, leading to a dynamic receptor with high functional plasticity. Cooperative regulation of different intracellular effectors (MAPK, Akt, transcription factors) by α1-adrenoceptors, hormones or growth factors has been suggested. The prostatic α1-adrenoceptor is no longer being regarded as an isolated, static receptor exclusively mediating prostatic smooth muscle contraction by G proteins, but a dynamic receptor interacting with other receptors within a complex network of mediators. Neurourol. Urodynam. 33:1074–1085, 2014. © 2013 Wiley Periodicals, Inc.