Conflict of interest: none.
Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis
Article first published online: 22 OCT 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 34, Issue 1, pages 86–91, January 2015
How to Cite
Bae, W.-J., Ha, U.-S., Kim, S., Kim, S.-J., Hong, S.-H., Lee, J.-Y., Hwang, T.-K., Hwang, S.-Y., Kim, H.-J. and Kim, S.-W. (2015), Reduction of oxidative stress may play a role in the anti-inflammatory effect of the novel herbal formulation in a rat model of hydrochloric acid-induced cystitis. Neurourol. Urodyn., 34: 86–91. doi: 10.1002/nau.22507
Karl-Erik Andersson led the peer-review process as the Associate Editor responsible for the paper.
- Issue published online: 12 DEC 2014
- Article first published online: 22 OCT 2013
- Manuscript Accepted: 4 SEP 2013
- Manuscript Received: 24 MAY 2013
- Ministry of Health & Welfare, Republic of Korea. Grant Number: F110004
We investigated the effect of the multi-herbal medicine, WSY-1075 in an animal model of hydrochloric acid (HCl)-induced cystitis.
Rats were randomly assigned to three groups: sham-operated (control), HCl-induced only (HC), and HC treated with WSY-1075 (HC + WT). Oral administration of either distilled water (control, HC) or WSY-1075 (400 mg/kg) was continued for 4 weeks. In HC and HC + WT groups, cystitis was induced with 0.4 M HCl beginning on the 22nd day. Rats in each group underwent cystometrography, and bladders were examined for evidence of inflammation and oxidative stress.
Treatment with WSY-1075 decreased the frequency of urination and reduced inflammation of the bladder tissue in a rat model of HCl-induced cystitis. Compared with the control group, the HC group showed severe chronic inflammatory and fibrosis signs, and the inflammatory grades significantly decreased following WSY-1075 treatment in the HC-WT group. The HC + WT group showed a markedly decreased expression of pro-inflammatory cytokines compared to the HC group. The level of malondialdehyde was significantly greater in the HC group compared to the control group, and it was significantly reduced in the treated (HC + WT) group. The levels of superoxide dismutase increased in the HC + WT group, which confirmed the anti-oxidant effect of WSY-1075.
We suggest that reduction of oxidative stress may play a role in this anti-inflammatory effect. Neurourol. Urodynam. 34:86–91, 2015. © 2013 Wiley Periodicals, Inc.