Heinz Koelbl led the peer-review process as the Associate Editor responsible for the paper.
The impact of tension-free vaginal tape on the urethral closure function: Mechanism of action
Article first published online: 8 NOV 2013
© 2013 Wiley Periodicals, Inc.
Neurourology and Urodynamics
Volume 34, Issue 1, pages 50–54, January 2015
How to Cite
Saaby, M.-L., Klarskov, N. and Lose, G. (2015), The impact of tension-free vaginal tape on the urethral closure function: Mechanism of action. Neurourol. Urodyn., 34: 50–54. doi: 10.1002/nau.22513
Conflict of interest: Gunnar Lose—Research cooperation with Coloplast under grant from Advanced Technology Foundation.
- Issue published online: 12 DEC 2014
- Article first published online: 8 NOV 2013
- Manuscript Accepted: 25 SEP 2013
- Manuscript Received: 27 JUN 2013
- closure function;
- closure mechanism;
- intra-abdominal pressure increase;
- pressure reflectometry;
- tension-free vaginal tape;
- urinary incontinence;
To investigate if the tension-free vaginal tape (TVT) works by increasing the abdominal to urethral pressure impact ratio (APIR).
Twenty one women with urodynamically proven stress urinary incontinence (SUI) were assessed by ICIQ-SF, pad-weighing test, incontinence diary and Urethral Pressure Reflectometry (UPR) before and after TVT. UPR was conducted during resting and increased intra-abdominal pressure (PAbd) by straining. Related values of PAbd and urethral opening pressure (Po) were plotted into an abdomino-urethral pressuregram. Linear regression of the values was conducted, and the slope of the line was found. The slope expresses the ratio of pressure increase in the urethra compared to the pressure increase in the abdomen and was called APIR.
The urethral opening pressure at rest (Po-rest) was unchanged after TVT, while APIR increased in all women (from 0.7 to 1.4, P < 0.0001).
The TVT seems to strengthen the urethral closure function by increasing the APIR while Po-rest is unchanged regardless of the type of pre-operative dysfunction. This confirms the theory of TVT's mechanism of action being mid-urethral support. Neurourol. Urodynam. 34:50–54, 2015. © 2013 Wiley Periodicals, Inc.