Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis: A cohort study from Taiwan

Authors

  • Shiu-Dong Chung,

    1. Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao, Taipei, Taiwan
    2. Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan
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  • Sudha Xirasagar,

    1. Arnold School of Public Health, Department of Health Services Policy and Management, University of South Carolina, Columbia, South Carolina
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  • Ching-Chun Lin,

    1. Department of Psychology, Saint Louis University, St. Louis, Missouri
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  • Wells Ling,

    1. Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan
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  • Hsien-Chang Li,

    1. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
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  • Herng-Ching Lin

    Corresponding author
    1. Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan
    2. School of Health Care Administration, Taipei Medical University, Taipei, Taiwan
    • Correspondence to: Herng-Ching Lin, PhD, School of Health Care Administration, College of Medicine, Taipei Medical University, 250 Wu-Hsing St., Taipei 110, Taiwan. E-mail: henry11111@tmu.edu.tw

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  • Eric Rovner led the peer-review process as the Associate Editor responsible for the paper.
  • The authors declare that they have no conflict of interest.
  • Herng-Ching Lin and Hsien-Chang Li have equal contributions to this study.
  • No funding sources.

Abstract

Aim

Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow-up, compared to controls without a BPS/IC diagnosis.

Methods

This retrospective cohort study used data retrieved from the Taiwan “Longitudinal Health Insurance Database 2000.” We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow-up.

Results

The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78–27.07) and 11.65 (95% CI: 9.88–13.64) per 1,000 person-years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09–2.14) in the BPS/IC group relative to the comparison group over 3-year follow-up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02–2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk.

Conclusions

Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44–49, 2015. © 2013 Wiley Periodicals, Inc.

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