This manuscript is original and the data presented here has not been published in prior journals.
Original Basic Science Article
Tamsulosin modulates, but does not abolish the spontaneous activity in the guinea pig prostate gland
Article first published online: 16 JAN 2014
© 2014 Wiley Periodicals, Inc.
Neurourology and Urodynamics
How to Cite
Chakrabarty, B., Dey, A., Lam, M., Ventura, S. and Exintaris, B. (2014), Tamsulosin modulates, but does not abolish the spontaneous activity in the guinea pig prostate gland. Neurourol. Urodyn.. doi: 10.1002/nau.22557
Lori Birder led the peer-review process as the Associate Editor responsible for the paper.
Conflict of interest: none.
- Article first published online: 16 JAN 2014
- Manuscript Accepted: 13 DEC 2013
- Manuscript Received: 24 SEP 2013
- National Health and Medical Research Council of Australia
- guinea pig;
- smooth muscle;
- spontaneous contractions;
To examine the effects of the α1A-adrenoceptor antagonist, tamsulosin, on spontaneous contractile and electrical activity in the guinea-pig prostate gland.
The effects of tamsulosin (0.1 and 0.3 nM) were investigated in adult and ageing male guinea pig prostate glands using conventional tension recording and electrophysiological intracellular microelectrode recording techniques.
Tamsulosin reduced spontaneous activity, and had different age-dependent effects on adult and ageing guinea pigs at different concentrations. 0.1 nM tamsulosin caused a significantly greater reduction of spontaneous contractile and electrical activity in ageing guinea pigs in comparison to adult guinea pigs. In contrast, 0.3 nM tamsulosin had a significantly greater reduction of spontaneous contractile and electrical activity in adult guinea pigs in comparison to ageing guinea pigs.
This study demonstrates that tamsulosin can modulate spontaneous myogenic stromal contractility and the underlying spontaneous electrical activity; tamsulosin does not block spontaneous activity. This reduction in spontaneous activity suggests that downstream cellular mechanisms underlying smooth muscle tone are being targeted, and these may represent novel therapeutic targets to better treat benign prostatic hyperplasia. Neurourol. Urodynam. © 2014 Wiley Periodicals, Inc.