Review Article

You have free access to this content

Role of proton MR for the study of muscle lipid metabolism†

  1. Chris Boesch1,*,
  2. Juergen Machann2,
  3. Peter Vermathen1,
  4. Fritz Schick2

Article first published online: 31 OCT 2006

DOI: 10.1002/nbm.1096

Issue

NMR in Biomedicine

NMR in Biomedicine

Volume 19, Issue 7, pages 968–988, November 2006

Additional Information

How to Cite

Boesch, C., Machann, J., Vermathen, P. and Schick, F. (2006), Role of proton MR for the study of muscle lipid metabolism. NMR Biomed., 19: 968–988. doi: 10.1002/nbm.1096

Author Information

  1. 1

    Department of Clinical Research (AMSM), University of Bern, Bern, Switzerland

  2. 2

    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard-Karls-University of Tübingen, Tübingen, Germany

*University of Bern, Department of Clinical Research (AMSM), MR Center 1, University and Inselspital, CH-3010 Bern, Switzerland.

  1. †

    This paper is published as part of a Special Issue entitled “NMR of the Musculoskeletal System”.

Publication History

  1. Issue published online: 31 OCT 2006
  2. Article first published online: 31 OCT 2006
  3. Manuscript Revised: 26 JUL 2006
  4. Manuscript Accepted: 26 JUL 2006
  5. Manuscript Received: 30 JAN 2006

Funded by

  • Swiss National Science Foundation. Grant Number: 3100A0-105815
  • Deutsche Forschungsgemeinschaft. Grant Number: KFO 114

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (507K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Giulio Gambarota, Robert L. Janiczek, Robert V. Mulkern, Rexford D. Newbould, An NMR Phantom Mimicking Intramyocellular (IMCL) and Extramyocellular Lipids (EMCL), Applied Magnetic Resonance, 2012,

    CrossRef

  2. 2
    Jimin Ren, Susan Lakoski, Ronald G. Haller, A. Dean Sherry, Craig R. Malloy, Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS, Magnetic Resonance in Medicine, 2012, 67, 6
    Direct Link:
  3. 3
    Małgorzata Marjańska, Lynn E. Eberly, Gregor Adriany, Sarah N. Verdoliva, Michael Garwood, Lisa Chow, Influence of foot orientation on the appearance and quantification of 1H magnetic resonance muscle spectra obtained from the soleus and the vastus lateralis, Magnetic Resonance in Medicine, 2012, 67, 6
    Direct Link:
  4. 4
    Tania Buehler, Nicolas Ramseier, Juergen Machann, Nina F. Schwenzer, Chris Boesch, Magnetic resonance imaging based determination of body compartments with the versatile, interactive sparse sampling (VISS) method, Journal of Magnetic Resonance Imaging, 2012, 35, 6
    Direct Link:
  5. 5
    Richard A. M. Jonkers, Tom R. Geraedts, Luc J. C. van Loon, Klaas Nicolay, Jeanine J. Prompers, Multitissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] magnetic resonance spectroscopy, Magnetic Resonance in Medicine, 2012, 67, 6
    Direct Link:
  6. 6
    Vaclav Brandejsky, Roland Kreis, Chris Boesch, Restricted or severely hindered diffusion of intramyocellular lipids in human skeletal muscle shown by in vivo proton MR spectroscopy, Magnetic Resonance in Medicine, 2012, 67, 2
    Direct Link:
  7. 7
    Peter Vermathen, Pierre Saillen, Andreas Boss, Monica Zehnder, Chris Boesch, Skeletal muscle 1H MRSI before and after prolonged exercise. I. muscle specific depletion of intramyocellular lipids, Magnetic Resonance in Medicine, 2012, 67, 6
    Direct Link:
  8. 8
    Andreas Boss, Roland Kreis, Pierre Saillen, Monica Zehnder, Chris Boesch, Peter Vermathen, Skeletal muscle 1H MRSI before and after prolonged exercise. II. visibility of free carnitine, Magnetic Resonance in Medicine, 2012, 67, 6
    Direct Link:
  9. 9
    Arunima Pola, Suresh Anand Sadananthan, Jadegoud Yaligar, Vijayasarathi Nagarajan, Weiping Han, Philip W. Kuchel, S. Sendhil Velan, Skeletal muscle lipid metabolism studied by advanced magnetic resonance spectroscopy, Progress in Nuclear Magnetic Resonance Spectroscopy, 2012,

    CrossRef

  10. 10
    Li Xiao, Ed X. Wu, Diffusion-weighted magnetic resonance spectroscopy: A novel approach to investigate intramyocellular lipids, Magnetic Resonance in Medicine, 2011, 66, 4
    Direct Link:
  11. 11
    Atiyah Yahya, Anthony G. Tessier, B. Gino Fallone, Effect of J-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T, Journal of Magnetic Resonance Imaging, 2011, 34, 6
    Direct Link:
  12. 12
    Robert D. O'Connor, Jian Xu, Gregory A. Ewald, Joseph J. H. Ackerman, Linda R. Peterson, Robert J. Gropler, Adil Bashir, Intramyocardial triglyceride quantification by magnetic resonance spectroscopy: In vivo and ex vivo correlation in human subjects, Magnetic Resonance in Medicine, 2011, 65, 5
    Direct Link:
  13. 13
    Qiong Ye, Carsten Friedrich Danzer, Alexander Fuchs, Wilhelm Krek, Thomas Mueggler, Christof Baltes, Markus Rudin, Longitudinal evaluation of intramyocellular lipids (IMCLs) in tibialis anterior muscle of ob/ob and ob/+ control mice using a cryogenic surface coil at 9.4 T, NMR in Biomedicine, 2011, 24, 10
    Direct Link:
  14. 14
    Jürgen Machann, Norbert Stefan, Andreas Fritsche, Fritz Schick, Magnetic resonance techniques for mapping fat deposits and directing therapy, Clinical Lipidology, 2011, 6, 1, 93

    CrossRef

  15. 15
    Dragana Lavrnic, Marko Dakovic, Stojan Peric, Vidosava Rakocevic-Stojanovic, Ivana Basta, Ivan Marjanovic, Tatjana Stosic-Opincal, Slobodan Lavrnic, Proton magnetic resonance spectroscopy of the intrinsic tongue muscles in patients with myasthenia gravis with different autoantibodies, Journal of the Neurological Sciences, 2011, 302, 1-2, 25

    CrossRef

  16. 16
    Dimitrios C. Karampinos, Huanzhou Yu, Ann Shimakawa, Thomas M. Link, Sharmila Majumdar, T1-corrected fat quantification using chemical shift-based water/fat separation: Application to skeletal muscle, Magnetic Resonance in Medicine, 2011, 66, 5
    Direct Link:
  17. 17
    Xin Wang, Michael A. Jacobs, Laura Fayad, Therapeutic response in musculoskeletal soft tissue sarcomas: evaluation by MRI, NMR in Biomedicine, 2011, 24, 6
    Direct Link:
  18. 18
    Jimin Ren, A. Dean Sherry, Craig R. Malloy, 1H MRS of intramyocellular lipids in soleus muscle at 7 T: Spectral simplification by using long echo times without water suppression, Magnetic Resonance in Medicine, 2010, 64, 3
    Direct Link:
  19. 19
    Diego Hernando, Zhi-Pei Liang, Peter Kellman, Chemical shift–based water/fat separation: A comparison of signal models, Magnetic Resonance in Medicine, 2010, 64, 3
    Direct Link:
  20. 20
    Marc-André Weber, Wulf Hildebrandt, Leif Schröder, Ralf Kinscherf, Martin Krix, Peter Bachert, Stefan Delorme, Marco Essig, Hans-Ulrich Kauczor, Holger Krakowski-Roosen, Concentric resistance training increases muscle strength without affecting microcirculation, European Journal of Radiology, 2010, 73, 3, 614

    CrossRef

  21. 21
    Scott Lipnick, Gaurav Verma, Saadallah Ramadan, Jon Furuyama, M. Albert Thomas, Echo planar correlated spectroscopic imaging: Implementation and pilot evaluation in human calf in vivo, Magnetic Resonance in Medicine, 2010, 64, 4
    Direct Link:
  22. 22
    James M. Elliott, Shaun OʼLeary, Michele Sterling, Joan Hendrikz, Ashley Pedler, Gwen Jull, Magnetic Resonance Imaging Findings of Fatty Infiltrate in the Cervical Flexors in Chronic Whiplash, Spine, 2010, 35, 9, 948

    CrossRef

  23. 23
    Marinette van der Graaf, Cees J. Tack, Jacco H. de Haan, Dennis W. J. Klomp, Arend Heerschap, Magnetic resonance spectroscopy shows an inverse correlation between intramyocellular lipid content in human calf muscle and local glycogen synthesis rate, NMR in Biomedicine, 2010, 23, 2
    Direct Link:
  24. 24
    Francisco Ortiz-Nieto, Lars Johansson, Håkan Ahlström, Jan Weis, Quantification of lipids in human lower limbs using yellow bone marrow as the internal reference: gender-related effects, Magnetic Resonance Imaging, 2010, 28, 5, 676

    CrossRef

  25. 25
    Michael Ith, Philipp M. Huber, Andrea Egger, Jean-Paul Schmid, Roland Kreis, Emanuel Christ, Chris Boesch, Standardized protocol for a depletion of intramyocellular lipids (IMCL), NMR in Biomedicine, 2010, 23, 5
    Direct Link:
  26. 26
    Atiyah Yahya, B. Gino Fallone, T2 determination of the J-coupled methyl protons of lipids: In vivo ilustration with tibial bone marrow at 3 T, Journal of Magnetic Resonance Imaging, 2010, 31, 6
    Direct Link:
  27. You have free access to this content27
    Robert D. O’Connor, Adil Bashir, W. Todd Cade, Kevin E. Yarasheski, Robert J. Gropler, 1H-Magnetic Resonance Spectroscopy for Quantifying Myocardial Lipid Content in Humans With the Cardiometabolic Syndrome, The Journal of Clinical Hypertension, 2009, 11, 9
    Direct Link:
  28. 28
    Jan Weis, Lars Johansson, Francisco Ortiz-Nieto, Håkan Ahlström, Assessment of lipids in skeletal muscle by LCModel and AMARES, Journal of Magnetic Resonance Imaging, 2009, 30, 5
    Direct Link:
  29. 29
    Klaus Brechtel, Juergen Machann, Margarete Pick, Juergen F. Schaefer, Claus D. Claussen, Fritz Schick, Changes in Muscular Lipids in Unilateral Isolated Hypertrophy of Gastrocnemius Muscle Can Be Revealed by1H MR Spectroscopy, Korean Journal of Radiology, 2009, 10, 6, 581

    CrossRef

  30. 30
    Rachida Fissoune, Marc Janier, André Briguet, Bassem Hiba, In Vivo Assessment of Mouse Hindleg Intramyocellular Lipids by 1H-MR Spectroscopy, Academic Radiology, 2009, 16, 7, 890

    CrossRef

  31. 31
    Michael Neumaier, Heiko G. Niessen, Thomas Kaulisch, Detlef Stiller, Inductively coupled helmholtz coil on a dedicated imaging platform for the in vivo1H-MRS measurement of intramyocellular lipids in the hind leg of rats, Magnetic Resonance in Medicine, 2009, 62, 4
    Direct Link:
  32. 32
    Tsyh-Jyi Hsieh, Twei-Shiun Jaw, Hung-Yi Chuang, Yuh-Jyh Jong, Gin-Chang Liu, Chun-Wei Li, Muscle Metabolism in Duchenne Muscular Dystrophy Assessed by In Vivo Proton Magnetic Resonance Spectroscopy, Journal of Computer Assisted Tomography, 2009, 33, 1, 150

    CrossRef

  33. 33
    Anthony Khuu, Jimin Ren, Ivan Dimitrov, Donald Woessner, James Murdoch, A. Dean Sherry, Craig R. Malloy, Orientation of lipid strands in the extracellular compartment of muscle: Effect on quantitation of intramyocellular lipids, Magnetic Resonance in Medicine, 2009, 61, 1
    Direct Link:
  34. 34
    T. Lang, T. Streeper, P. Cawthon, K. Baldwin, D. R. Taaffe, T. B. Harris, Sarcopenia: etiology, clinical consequences, intervention, and assessment, Osteoporosis International, 2009, 21, 4, 543

    CrossRef

  35. You have free access to this content35
    Clare P. Bernard, Gary P. Liney, David J. Manton, Lindsay W. Turnbull, Christian M. Langton, Comparison of fat quantification methods: A phantom study at 3.0T, Journal of Magnetic Resonance Imaging, 2008, 27, 1
    Direct Link:
  36. 36
    Michele Gaeta, Fabio Minutoli, Antonio Toscano, Antonio Celona, Olimpia Musumeci, Sergio Racchiusa, Silvio Mazziotti, Opposed-phase MR imaging of lipid storage myopathy in a case of Chanarin–Dorfman disease, Skeletal Radiology, 2008, 37, 11, 1053

    CrossRef

  37. 37
    Marc-André Weber, Holger Krakowski-Roosen, Wulf Hildebrandt, Leif Schröder, Ingrid Ionescu, Martin Krix, Ralf Kinscherf, Peter Bachert, Hans-Ulrich Kauczor, Marco Essig, Assessment of Metabolism and Microcirculation of Healthy Skeletal Muscles by Magnetic Resonance and Ultrasound Techniques, Journal of Neuroimaging, 2007, 17, 4
    Direct Link:
  38. 38
    Tsyh-Jyi Hsieh, Chien-Kuo Wang, Hung-Yi Chuang, Yuh-Jyh Jong, Chun-Wei Li, Gin-Chung Liu, In Vivo Proton Magnetic Resonance Spectroscopy Assessment for Muscle Metabolism in Neuromuscular Diseases, The Journal of Pediatrics, 2007, 151, 3, 319

    CrossRef

  39. 39
    Robert D. O’Connor, Robert J. Gropler, Linda Peterson, Jean Schaffer, Joseph J.H. Ackerman, Limits of a localized magnetic resonance spectroscopy assay for ex vivo myocardial triacylglycerol, Journal of Pharmaceutical and Biomedical Analysis, 2007, 45, 3, 382

    CrossRef

  40. 40
    Chris Boesch, Musculoskeletal spectroscopy, Journal of Magnetic Resonance Imaging, 2007, 25, 2
    Direct Link:
  41. 41
    Chris Boesch, Boesch, Chris: From NMR in 5-mm Tubes to Magnetic Resonance Spectroscopy (MRS) in Humans, Encyclopedia of Magnetic Resonance,
    Direct Link:
  42. 42
    Geoffrey S. Payne, Basetti Madhu, John R. Griffiths, Development of NMR: Biological and Medical MR Spectroscopy, Encyclopedia of Magnetic Resonance,
    Direct Link:
  43. 43
    Chris Boesch, Human Muscle Studies by Magnetic Resonance Spectroscopy, Encyclopedia of Magnetic Resonance,
    Direct Link:
Get PDF (507K)