In Vivo mouse imaging and spectroscopy in drug discovery
Article first published online: 24 APR 2007
Copyright © 2007 John Wiley & Sons, Ltd.
NMR in Biomedicine
Special Issue: MR of Transgenic Mice
Volume 20, Issue 3, pages 154–185, May 2007
How to Cite
Beckmann, N., Kneuer, R., Gremlich, H.-U., Karmouty-Quintana, H., Blé, F.-X. and Müller, M. (2007), In Vivo mouse imaging and spectroscopy in drug discovery. NMR Biomed., 20: 154–185. doi: 10.1002/nbm.1153
- Issue published online: 24 APR 2007
- Article first published online: 24 APR 2007
- Manuscript Revised: 28 DEC 2006
- Manuscript Accepted: 28 DEC 2006
- Manuscript Received: 23 JUN 2006
- near-infrared fluorescence imaging;
- transgenic mice;
Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease. Copyright © 2007 John Wiley & Sons, Ltd.