A preliminary version of this work was presented in an oral scientific session at the 14th Annual Meeting of the International Society for Magnetic Resonance in Medicine, 9 May 2006, Seattle, WA, USA.
Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T 1H MRS imaging study†
Article first published online: 21 OCT 2008
Copyright © 2008 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 22, Issue 3, pages 251–258, April 2009
How to Cite
Mathew, S. J., Mao, X., Keegan, K. A., Levine, S. M., Smith, E. L. P., Heier, L. A., Otcheretko, V., Coplan, J. D. and Shungu, D. C. (2009), Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T 1H MRS imaging study. NMR Biomed., 22: 251–258. doi: 10.1002/nbm.1315
- Issue published online: 3 MAR 2009
- Article first published online: 21 OCT 2008
- Manuscript Accepted: 7 JUL 2008
- Manuscript Revised: 6 JUL 2008
- Manuscript Received: 2 JUN 2008
- CFIDS Association of America, Inc.
- Weill Cornell Medical College New Faculty Development Funds
- National Institutes of Health. Grant Numbers: K23-MH-069656, MO1-RR-00071
- brain metabolism;
- chronic fatigue syndrome;
- anxiety disorder;
- cerebrospinal fluid
Chronic fatigue syndrome (CFS) is a controversial diagnosis because of the lack of biomarkers for the illness and its symptom overlap with neuropsychiatric, infectious, and rheumatological disorders. We compared lateral ventricular volumes derived from tissue-segmented T1-weighted volumetric MRI data and cerebrospinal fluid (CSF) lactate concentrations measured by proton MRS imaging (1H MRSI) in 16 subjects with CFS (modified US Centers for Disease Control and Prevention criteria) with those in 14 patients with generalized anxiety disorder (GAD) and in 15 healthy volunteers, matched group-wise for age, sex, body mass index, handedness, and IQ. Mean lateral ventricular lactate concentrations measured by 1H MRSI in CFS were increased by 297% compared with those in GAD (P < 0.001) and by 348% compared with those in healthy volunteers (P < 0.001), even after controlling for ventricular volume, which did not differ significantly between the groups. Regression analysis revealed that diagnosis accounted for 43% of the variance in ventricular lactate. CFS is associated with significantly raised concentrations of ventricular lactate, potentially consistent with recent evidence of decreased cortical blood flow, secondary mitochondrial dysfunction, and/or oxidative stress abnormalities in the disorder. Copyright © 2008 John Wiley & Sons, Ltd.