Some of these results were presented at the 2008 Conference on Retroviruses and Opportunistic Infections (CROI) 3–6 February 2008, Boston, MA, USA.
Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients†
Article first published online: 5 NOV 2008
Copyright © 2008 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 22, Issue 3, pages 326–331, April 2009
How to Cite
Sailasuta, N., Shriner, K. and Ross, B. (2009), Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients. NMR Biomed., 22: 326–331. doi: 10.1002/nbm.1329
- Issue published online: 3 MAR 2009
- Article first published online: 5 NOV 2008
- Manuscript Accepted: 26 JUL 2008
- Manuscript Revised: 18 JUN 2008
- Manuscript Received: 31 MAR 2008
- highly active retroviral therapy (HAART);
- frontal lobe;
- central nervous system;
- HIV-associated dementia
Neurological complications associated with the acquired immunodeficiency syndrome, in particular, HIV-associated dementia, continue to plague those infected. We report our finding that the concentration of brain Glu is reduced in the frontal white matter region in this condition. In addition, our data appear to absolve highly active retroviral therapy (HAART) from blame, as drug-naïve patients were equally affected. Our findings suggest that Glu neurotransmission is abnormal and may be a key target for early interventions to reduce the later incidence of neurocognitive impairment and dementia among HIV-seropositive patients. Copyright © 2008 John Wiley & Sons, Ltd.