These authors contributed equally to this work.
Blood–spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI
Article first published online: 20 NOV 2008
Copyright © 2008 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 22, Issue 3, pages 332–341, April 2009
How to Cite
Cohen, D. M., Patel, C. B., Ahobila-Vajjula, P., Sundberg, L. M., Chacko, T., Liu, S.-J. and Narayana, P. A. (2009), Blood–spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI. NMR Biomed., 22: 332–341. doi: 10.1002/nbm.1343
- Issue published online: 3 MAR 2009
- Article first published online: 20 NOV 2008
- Manuscript Accepted: 6 AUG 2008
- Manuscript Revised: 5 AUG 2008
- Manuscript Received: 11 MAR 2008
- NIH/NINDS. Grant Number: NS045624
- NIH/NCRR. Grant Number: S10 RR17205
- spinal cord injury;
- blood–spinal cord barrier;
- dynamic contrast-enhanced MRI;
- focal enhancement;
- diffuse enhancement;
- normal appearing white matter;
- Basso–Beattie–Bresnahan (BBB) score
After a primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood–spinal cord barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast-enhanced MRI (DCE-MRI) studies were performed up to 56 days after SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post-contrast MRI (non-enhancing tissue). DCE-MRI data were analyzed using a two-compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post-SCI time. However, on the basis of DCE-MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days after SCI. In addition, open-field locomotion was evaluated using the 21-point Basso–Beattie–Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed. Copyright © 2008 John Wiley & Sons, Ltd.