This article is a US Government work and is in the public domain in the USA.
Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex†
Article first published online: 25 MAR 2009
This article is a US Government work and is in the public domain in the USA. Published in 2009 by John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 22, Issue 7, pages 730–736, August 2009
How to Cite
Bock, N. A., Kocharyan, A. and Silva, A. C. (2009), Manganese-enhanced MRI visualizes V1 in the non-human primate visual cortex. NMR Biomed., 22: 730–736. doi: 10.1002/nbm.1384
- Issue published online: 7 AUG 2009
- Article first published online: 25 MAR 2009
- Manuscript Revised: 4 FEB 2009
- Manuscript Accepted: 4 FEB 2009
- Manuscript Received: 26 AUG 2008
- Intramural Research Program of the NIH, NINDS
- manganese-enhanced MRI (MEMRI);
- visual cortex;
- non-human primate;
- Gennari stripe;
- cytochrome oxidase
MRI at 7 Tesla has been used to investigate the accumulation of manganese in the occipital cortex of common marmoset monkeys (Callithrix jacchus) after administering four fractionated injections of 30 mg/kg MnCl2 · 4H2O in the tail vein. We found a statistically significant decrease in T1 in the primary (V1) and secondary (V2) areas of the visual cortex caused by an accumulation of manganese. The larger T1 shortening in V1 (ΔT1 = 640 ms) relative to V2 (ΔT1 = 490 ms) allowed us to robustly detect the V1/V2 border in vivo using heavily T1-weighted MRI. Furthermore, the dorso-medial (DM) and middle-temporal (MT) areas of the visual pathway could be identified by their T1-weighted enhancement. We showed by comparison to histological sections stained for cytochrome oxidase (CO) activity that the extent of V1 is accurately identified throughout the visual cortex by manganese-enhanced MRI (MEMRI). This provides a means of visualizing functional cortical regions in vivo and could be used in longitudinal studies of phenomena such as cortical plasticity, and for non-destructive localization of cortical regions to guide in the implementation of functional techniques. Published in 2009 by John Wiley & Sons, Ltd.