Regional determination of oxygen uptake in rodent lungs using hyperpolarized gas and an analytical treatment of intrapulmonary gas redistribution
Article first published online: 8 MAR 2011
Copyright © 2011 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 24, Issue 10, pages 1253–1263, December 2011
How to Cite
Kadlecek, S., Mongkolwisetwara, P., Xin, Y., Ishii, M., Profka, H., Emami, K. and Rizi, R. (2011), Regional determination of oxygen uptake in rodent lungs using hyperpolarized gas and an analytical treatment of intrapulmonary gas redistribution. NMR Biomed., 24: 1253–1263. doi: 10.1002/nbm.1685
- Issue published online: 3 JAN 2012
- Article first published online: 8 MAR 2011
- Manuscript Accepted: 10 JAN 2011
- Manuscript Revised: 9 DEC 2010
- Manuscript Received: 26 JUL 2010
A method is presented which allows for the accurate extraction of regional functional metrics in rodent lungs using hyperpolarized gas. The technique is based on the combination of measured T1 decay, an independent measure of specific ventilation and mass balance considerations to extract the regional oxygen levels and uptake. In phantom and animal experiments, it is demonstrated that the redistribution of gas during the measurement is a significant confounding factor, and this effect is addressed analytically. The resulting parameterization of gas flow increases the accuracy of oxygen-sensitive MRI, and may also be used independently to assess air trapping and airway constriction. Limitations of the technique with respect to spatial resolution and robustness are also discussed. Copyright © 2011 John Wiley & Sons, Ltd.