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Hyperpolarized 129Xe lung MRI in spontaneously breathing mice with respiratory gated fast imaging and its application to pulmonary functional imaging

Authors

  • Hirohiko Imai,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Atsuomi Kimura,

    Corresponding author
    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
    • Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1–7 Yamadaoka, Suita, Osaka 565-0871, Japan.

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  • Yuki Hori,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Satoshi Iguchi,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Takuya Kitao,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Emi Okubo,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Tsuyoshi Ito,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Toshio Matsuzaki,

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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  • Hideaki Fujiwara

    1. Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan
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Abstract

In the present study, a balanced steady-state free precession pulse sequence combined with compressed sensing was applied to hyperpolarized 129Xe lung imaging in spontaneously breathing mice. With the aid of fast imaging techniques, the temporal resolution was markedly improved in the resulting images. Using these protocols and respiratory gating, 129Xe lung images in end-inspiratory and end-expiratory phases were obtained successfully. The application of these techniques for pulmonary functional imaging made it possible to simultaneously evaluate regional ventilation and gas exchange in the same animal. A comparative study between healthy and elastase-induced mouse models of emphysema showed abnormal ventilation as well as gas exchange in elastase-treated mice. Copyright © 2011 John Wiley & Sons, Ltd.

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