Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T
Version of Record online: 25 JUL 2013
Copyright © 2013 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 26, Issue 12, pages 1672–1679, December 2013
How to Cite
Liu, Q., Jin, N., Fan, Z., Natsuaki, Y., Tawackoli, W., Pelled, G., Bae, H., Gazit, D. and Li, D. (2013), Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T. NMR Biomed., 26: 1672–1679. doi: 10.1002/nbm.3001
- Issue online: 20 NOV 2013
- Version of Record online: 25 JUL 2013
- Manuscript Accepted: 18 JUN 2013
- Manuscript Revised: 6 JUN 2013
- Manuscript Received: 11 MAR 2013
- intervertebral disc;
- reduced FOV;
- bowel movement
The reduced field-of-view (rFOV) turbo-spin-echo (TSE) technique, which effectively suppresses bowel movement artifacts, is developed for the purpose of chemical exchange saturation transfer (CEST) imaging of the intervertebral disc (IVD) in vivo. Attempts to quantify IVD CEST signals in a clinical setting require high reliability and accuracy, which is often compromised in the conventionally used technique. The proposed rFOV TSE CEST method demonstrated significantly superior reproducibility when compared with the conventional technique on healthy volunteers, implying it is a more reliable measurement. Phantom study revealed a linear relation between CEST signal and glycosaminoglycan (GAG) concentration. The feasibility of detecting IVD degeneration was demonstrated on a healthy volunteer, indicating that the proposed method is a promising tool to quantify disc degeneration. Copyright © 2013 John Wiley & Sons, Ltd.