Glutamate and glutamine: a review of in vivo MRS in the human brain
Version of Record online: 4 OCT 2013
Copyright © 2013 John Wiley & Sons, Ltd.
NMR in Biomedicine
Volume 26, Issue 12, pages 1630–1646, December 2013
How to Cite
Ramadan, S., Lin, A. and Stanwell, P. (2013), Glutamate and glutamine: a review of in vivo MRS in the human brain. NMR Biomed., 26: 1630–1646. doi: 10.1002/nbm.3045
- Issue online: 20 NOV 2013
- Version of Record online: 4 OCT 2013
- Manuscript Accepted: 8 SEP 2013
- Manuscript Revised: 8 AUG 2013
- Manuscript Received: 25 JUN 2012
- in vivo;
- one dimensional;
- two dimensional
Our understanding of the roles that the amino acids glutamate (Glu) and glutamine (Gln) play in the mammalian central nervous system has increased rapidly in recent times. Many conditions are known to exhibit a disturbance in Glu–Gln equilibrium, and the exact relationships between these changed conditions and these amino acids are not fully understood. This has led to increased interest in Glu/Gln quantitation in the human brain in an array of conditions (e.g. mental illness, tumor, neuro-degeneration) as well as in normal brain function.
Accordingly, this review has been undertaken to describe the increasing number of in vivo techniques available to study Glu and Gln separately, or pooled as ‘Glx’. The present MRS methods used to assess Glu and Gln vary in approach, complexity, and outcome, thus the focus of this review is on a description of MRS acquisition approaches, and an indication of relative utility of each technique rather than brain pathologies associated with Glu and/or Gln perturbation. Consequently, this review focuses particularly on (1) one-dimensional 1H MRS, (2) two-dimensional 1H MRS, and (3) one-dimensional 13C MRS techniques. Copyright © 2013 John Wiley & Sons, Ltd.