This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT-induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed. Copyright © 2001 John Wiley & Sons, Ltd.
effective magnetic field
flow sensitive alternating inversion recovery
gadolinium diethylenetriminepentaacetic acid
magnetic resonance angiography
magnetic resonance imaging
magnetization transfer ratio
specific absorption rate.