Magnetization transfer in MRI: a review

Authors


Abstract

This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT-induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed. Copyright © 2001 John Wiley & Sons, Ltd.

Abbreviations used:
Beff

effective magnetic field

CRMG

Carr–Purcell–Meiboom–Gill

CW

continuous wave

FAIR

flow sensitive alternating inversion recovery

Gd-DTPA

gadolinium diethylenetriminepentaacetic acid

MRA

magnetic resonance angiography

MRI

magnetic resonance imaging

MS

multiple sclerosis

MT

magnetization transfer

MTR

magnetization transfer ratio

RF

radio frequency

SAR

specific absorption rate.

Ancillary