Automatic quantitation of localized in vivo1H spectra with LCModel
Article first published online: 12 JUN 2001
Copyright © 2001 John Wiley & Sons, Ltd.
NMR in Biomedicine
Special Issue: NMR Spectroscopy Quantitation
Volume 14, Issue 4, pages 260–264, June 2001
How to Cite
Provencher, S. W. (2001), Automatic quantitation of localized in vivo1H spectra with LCModel. NMR Biomed., 14: 260–264. doi: 10.1002/nbm.698
- Issue published online: 12 JUN 2001
- Article first published online: 12 JUN 2001
- Manuscript Received: 2 JAN 2001
- Manuscript Accepted: 2 JAN 2001
- magnetic resonance spectroscopy;
- proton MRS;
- in vivo
The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model in vitro spectra from individual metabolite solutions. Complete model spectra, rather than individual resonances, are used in order to incorporate maximum prior information into the analysis. A nearly model-free constrained regularization method automatically accounts for the baseline and lineshape in vivo without imposing a restrictive parameterized form on them. LCModel is automatic (non-interactive) with no subjective input. Approximately maximum-likelihood estimates of the metabolite concentrations and their uncertainties (Cramér-Rao lower bounds) are obtained. LCModel analyses of spectra from users with fields from 1.5 to 9.4 T and a wide range of sequences, particularly with short TE, are used here to illustrate the capabilities and limitations of LCModel and proton MRS. Copyright © 2001 John Wiley & Sons, Ltd.