Diffusion-tensor MRI: theory, experimental design and data analysis – a technical review
Article first published online: 5 DEC 2002
Copyright © 2002 John Wiley & Sons, Ltd.
NMR in Biomedicine
Special Issue: Diffusion tensor imaging and axonal mapping - state of the art
Volume 15, Issue 7-8, pages 456–467, November - December 2002
How to Cite
Basser, P. J. and Jones, D. K. (2002), Diffusion-tensor MRI: theory, experimental design and data analysis – a technical review. NMR Biomed., 15: 456–467. doi: 10.1002/nbm.783
- Issue published online: 5 DEC 2002
- Article first published online: 5 DEC 2002
- Manuscript Accepted: 9 JAN 2002
- Manuscript Revised: 8 JAN 2002
- Manuscript Received: 16 NOV 2001
This article treats the theoretical underpinnings of diffusion-tensor magnetic resonance imaging (DT-MRI), as well as experimental design and data analysis issues. We review the mathematical model underlying DT-MRI, discuss the quantitative parameters that are derived from the measured effective diffusion tensor, and describe artifacts thet arise in typical DT-MRI acquisitions. We also discuss difficulties in identifying appropriate models to describe water diffusion in heterogeneous tissues, as well as in interpreting experimental data obtained in such issues. Finally, we describe new statistical methods that have been developed to analyse DT-MRI data, and their potential uses in clinical and multi-site studies. Copyright © 2002 John Wiley & Sons, Ltd.