Diffusion tensor imaging and aging – a review
Article first published online: 5 DEC 2002
Copyright © 2002 John Wiley & Sons, Ltd.
NMR in Biomedicine
Special Issue: Diffusion tensor imaging and axonal mapping - state of the art
Volume 15, Issue 7-8, pages 553–560, November - December 2002
How to Cite
Moseley, M. (2002), Diffusion tensor imaging and aging – a review. NMR Biomed., 15: 553–560. doi: 10.1002/nbm.785
- Issue published online: 5 DEC 2002
- Article first published online: 5 DEC 2002
- Manuscript Revised: 7 JAN 2002
- Manuscript Accepted: 7 JAN 2002
- Manuscript Received: 5 JUN 2001
- diffusion tensor imaging;
- diffusion-weighted imaging;
Diffusion-tensor imaging (DTI) non-invasively provides maps of microscopic structural information of oriented tissue in vivo, which is finding utility in studies of the aging population. In contrast to the white matter maturation process, investigators have observed significant declines in the white matter ordering in normal as well as in abnormal aging. These studies suggest that water proton non-random, anisotropic diffusion measured by DTI is highly sensitive to otherwise subtle disease processes not normally seen with conventional MRI tissue contrast mechanisms. Copyright © 2002 John Wiley & Sons, Ltd.