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Diffusion tensor imaging and aging – a review

  1. Michael Moseley*

Article first published online: 5 DEC 2002

DOI: 10.1002/nbm.785

Issue

NMR in Biomedicine

NMR in Biomedicine

Special Issue: Diffusion tensor imaging and axonal mapping - state of the art

Volume 15, Issue 7-8, pages 553–560, November - December 2002

Additional Information

How to Cite

Moseley, M. (2002), Diffusion tensor imaging and aging – a review. NMR Biomed., 15: 553–560. doi: 10.1002/nbm.785

Author Information

  1. Department of Radiology, Lucas MR Center, Stanford University School of Medicine, Stanford, CA 94305-5488 USA

*Department of Radiology, 1201 Welch Road, Lucas MR Center, Stanford University School of Medicine, Stanford, CA 94305-5488, USA

Publication History

  1. Issue published online: 5 DEC 2002
  2. Article first published online: 5 DEC 2002
  3. Manuscript Revised: 7 JAN 2002
  4. Manuscript Accepted: 7 JAN 2002
  5. Manuscript Received: 5 JUN 2001

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Keywords:

  • diffusion tensor imaging;
  • DTI;
  • diffusion-weighted imaging;
  • DWI;
  • MRI

Abstract

  1. Top of page
  2. Abstract
  3. REFERENCES

Diffusion-tensor imaging (DTI) non-invasively provides maps of microscopic structural information of oriented tissue in vivo, which is finding utility in studies of the aging population. In contrast to the white matter maturation process, investigators have observed significant declines in the white matter ordering in normal as well as in abnormal aging. These studies suggest that water proton non-random, anisotropic diffusion measured by DTI is highly sensitive to otherwise subtle disease processes not normally seen with conventional MRI tissue contrast mechanisms. Copyright © 2002 John Wiley & Sons, Ltd.

REFERENCES

  1. Top of page
  2. Abstract
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Abbreviations used:
AC-PC

anterior and posterior commissures line

AD

Alzheimer's dementia

ADC

apparent diffusion coefficient

CSF

cerebrospinal fluid

DTI

diffusion tensor imaging

DWI

diffusion-weighted imaging

EPI

echo planar imaging

FA

fractional anisotropy

FLAIR

fluid attenuation inversion recovery (an MRI sequence)

FOV

field of view

FSE

fast spin-echo (an MRI sequence)

IQ

intelligence quotient

MRI

magnetic resonance imaging

RA

relative anisotropy

WM

white matter

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