Diffusion tensor imaging and aging – a review

Authors

  • Michael Moseley

    Corresponding author
    1. Department of Radiology, Lucas MR Center, Stanford University School of Medicine, Stanford, CA 94305-5488 USA
    • Department of Radiology, 1201 Welch Road, Lucas MR Center, Stanford University School of Medicine, Stanford, CA 94305-5488, USA
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Abstract

Diffusion-tensor imaging (DTI) non-invasively provides maps of microscopic structural information of oriented tissue in vivo, which is finding utility in studies of the aging population. In contrast to the white matter maturation process, investigators have observed significant declines in the white matter ordering in normal as well as in abnormal aging. These studies suggest that water proton non-random, anisotropic diffusion measured by DTI is highly sensitive to otherwise subtle disease processes not normally seen with conventional MRI tissue contrast mechanisms. Copyright © 2002 John Wiley & Sons, Ltd.

Abbreviations used:
AC-PC

anterior and posterior commissures line

AD

Alzheimer's dementia

ADC

apparent diffusion coefficient

CSF

cerebrospinal fluid

DTI

diffusion tensor imaging

DWI

diffusion-weighted imaging

EPI

echo planar imaging

FA

fractional anisotropy

FLAIR

fluid attenuation inversion recovery (an MRI sequence)

FOV

field of view

FSE

fast spin-echo (an MRI sequence)

IQ

intelligence quotient

MRI

magnetic resonance imaging

RA

relative anisotropy

WM

white matter

Ancillary