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Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases – a review

  1. Mark A. Horsfield1,*,
  2. Derek K. Jones2

Article first published online: 5 DEC 2002

DOI: 10.1002/nbm.787

Issue

NMR in Biomedicine

NMR in Biomedicine

Special Issue: Diffusion tensor imaging and axonal mapping - state of the art

Volume 15, Issue 7-8, pages 570–577, November - December 2002

Additional Information

How to Cite

Horsfield, M. A. and Jones, D. K. (2002), Applications of diffusion-weighted and diffusion tensor MRI to white matter diseases – a review. NMR Biomed., 15: 570–577. doi: 10.1002/nbm.787

Author Information

  1. 1

    Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK

  2. 2

    Section for Old Age Psychiatry, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK

*Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK

Publication History

  1. Issue published online: 5 DEC 2002
  2. Article first published online: 5 DEC 2002
  3. Manuscript Revised: 7 SEP 2001
  4. Manuscript Accepted: 7 SEP 2001
  5. Manuscript Received: 5 JUN 2001

Funded by

  • Wellcome Trust. Grant Number: 054030/Z/98

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Keywords:

  • diffusion;
  • tensor;
  • MRI;
  • DTI;
  • white matter;
  • disease

Abstract

This paper reviews the current applications of diffusion-weighted and diffusion tensor MRI in diseases of the brain white matter. The contribution that diffusion-weighted imaging has made to our understanding of white matter diseases is critically appraised. The quantitative nature of diffusion MRI is one of its major attractions; however, this is offset by the more advanced hardware required to collect diffusion-weighted images reliably, and the more complex processing to produce quantitative parametric diffusion images. With the now common availability of scanners equipped to perform echo-planar imaging, the acquisition of diffusion tensor images is sure to become more widespread and routine. Copyright © 2002 John Wiley & Sons, Ltd.

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