Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla

Authors

  • Lana G. Kaiser,

    Corresponding author
    1. Department of Radiology, University of California–San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California, USA
    • VA Medical Center (114M), 4150 Clement St, San Francisco, CA 94121, USA.
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  • Norbert Schuff,

    1. Department of Radiology, University of California–San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California, USA
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  • Nathan Cashdollar,

    1. Department of Radiology, University of California–San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California, USA
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  • Michael W. Weiner

    1. Department of Radiology, University of California–San Francisco, MR Unit VA Medical Center at San Francisco, San Francisco, California, USA
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Abstract

The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test–retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects. Copyright © 2004 John Wiley & Sons, Ltd.

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