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Keywords:

  • scyllo-inositol;
  • myo-inositol;
  • taurine;
  • 4 T;
  • spectroscopy;
  • human brain;
  • white matter;
  • aging

Abstract

The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test–retest studies performed on 10 normal subjects demonstrated coefficient of variation for scyllo-inositol measurement of 37%, compared with 6% for N-acetyl aspartate. Comparisons between old and young subjects showed higher concentration of scyllo-inositol and myo-inositol in older subjects and a trend for a correlation between scyllo-inositol and myo-inositol levels across subjects. Copyright © 2004 John Wiley & Sons, Ltd.