Manganese-enhanced magnetic resonance imaging (MEMRI)
Article first published online: 23 DEC 2004
Copyright © 2004 John Wiley & Sons, Ltd.
NMR in Biomedicine
Special Issue: Manganese-enhanced magnetic resonance imaging (MEMRI)
Volume 17, Issue 8, pages 527–531, November/December 2004
How to Cite
Koretsky, A. P. and Silva, A. C. (2004), Manganese-enhanced magnetic resonance imaging (MEMRI). NMR Biomed., 17: 527–531. doi: 10.1002/nbm.940
- Issue published online: 23 DEC 2004
- Article first published online: 23 DEC 2004
- Manuscript Revised: 6 OCT 2004
- Manuscript Accepted: 6 OCT 2004
- Manuscript Received: 3 OCT 2004
- neuronal-tract tracer;
- contrast agents
Manganese ion (Mn2+) is an essential metal that participates as a cofactor in a number of critical biological functions, such as electron transport, detoxification of free radicals and synthesis of neurotransmitters. Mn2+ can enter excitable cells using some of the same transport systems as Ca2+ and it can bind to a number of intracellular sites because it has high affinity for Ca2+ and Mg2+ binding sites on proteins and nucleic acids. Paramagnetic forms of manganese ions are potent MRI relaxation agents. Indeed, Mn2+ was the first contrast agent proposed for use in MRI. Recently, there has been renewed interest in combining the strong MRI relaxation effects of Mn2+ with its unique biology, in order to further expand the already broad assortment of useful information that can be measured by MRI. Such an approach has been continuously developed in the past several years to provide unique tissue contrast, to assess tissue viability, to act as a surrogate marker of calcium influx into cells and to trace neuronal connections. This special issue of NMR in Biomedicine on manganese-enhanced MRI (MEMRI) is aimed at providing the readers of this journal with an extensive review of some of the most prominent applications of MEMRI in biological systems. Written by several of the leaders in the field, the reviews and original research articles featured in this special issue are likely to offer an exciting and inspiring view of the broad range of applications of MEMRI. Copyright © 2004 John Wiley & Sons, Ltd.