NMR in Biomedicine

Cover image for NMR in Biomedicine

February 2009

Volume 22, Issue 2

Pages 137–249

  1. Research Articles

    1. Top of page
    2. Research Articles
    3. Book Reviews
    4. Current Awareness
    1. k-space analysis of point-resolved spectroscopy (PRESS) with regard to spurious echoes in in vivo1H MRS (pages 137–147)

      G. Starck, Å. Carlsson, M. Ljungberg and E. Forssell-Aronsson

      Version of Record online: 1 SEP 2008 | DOI: 10.1002/nbm.1289

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      Spurious signals of the PRESS sequence are analyzed using the concept of k- space. This new approach is well suited for studying the effect of gradient spoiling and refocusing of signal. k- space description of spurious echoes combined with Fourier analysis of realistic slice profiles, demonstrate that unsuppressed water signal in outer regions heavily increases the demands on spoiling. Several ways to improve PRESS measurements regarding suppression of spurious signal are discussed.

    2. First-pass dynamic contrast-enhanced MRI with extravasating contrast reagent: evidence for human myocardial capillary recruitment in adenosine-induced hyperemia (pages 148–157)

      Xin Li, Charles S. Springer Jr and Michael Jerosch-Herold

      Version of Record online: 26 AUG 2008 | DOI: 10.1002/nbm.1293

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      In human myocardial DCE MRI, a quadratic function was found to better describe the increase of vb vs. F, suggesting capillary recruitment. Renkin-Crone equation with a constant PCRS is not sufficient to describe the Ktrans increase with blood flow.

    3. Effect of phosphate electrolyte buffer on the dynamics of water in tendon and cartilage (pages 158–164)

      ShaoKuan Zheng and Yang Xia

      Version of Record online: 21 AUG 2008 | DOI: 10.1002/nbm.1294

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      This study has two important implications. For in vitro cartilage research, this work attests to the importance of the salty solution where the specimen is stored - not all salts have the same effect on the measurable quantities in NMR and MRI. For in vivo cartilage diagnosis, this work suggests the possibility of using a suitable electrolyte as a novel contrast agent to assess the ultrastructural changes in cartilage due to tissue degradation.

    4. Manganese-enhanced MRI of acute cardiac ischemia and chronic infarction in pig hearts: kinetic analysis of enhancement development (pages 165–173)

      Y. Yang, M. L. H. Gruwel, J. Sun, P. Gervai, X. Yang and V. V. Kupriyanov

      Version of Record online: 28 AUG 2008 | DOI: 10.1002/nbm.1297

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      Manganese ion is an intracellular type deposit contrast agent. It delineates region of severe acute ischemia as hypointensive area due to flow limitations and associated metabolic changes. In chronic infarct setting Mn2+. shows necrotic area owing to severely reduced number of viable cells.

    5. Diffusion-weighted imaging of the entire spinal cord (pages 174–181)

      B. J. Wilm, U. Gamper, A. Henning, K. P. Pruessmann, S. S. Kollias and P. Boesiger

      Version of Record online: 26 AUG 2008 | DOI: 10.1002/nbm.1298

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      In-vivo MR diffusion-weighted imaging is of significant clinical interest as a means of non-invasively providing information about structural integrity of neural tissue. In the spinal cord, physiological motion and strong susceptibility effects compromise achievable image quality. We herein present a single-shot diffusion-weighted EPI sequence that is insensitive to these effects, thereby allowing for high-resolution acquisition of the entire spinal cord.

    6. Diffusion tensor imaging of left ventricular remodeling in response to myocardial infarction in the mouse (pages 182–190)

      Gustav J. Strijkers, Annemiek Bouts, W. Matthijs Blankesteijn, Tim H. J. M. Peeters, Anna Vilanova, Mischa C. van Prooijen, Honorius M. H. F. Sanders, Edwin Heijman and Klaas Nicolay

      Version of Record online: 8 SEP 2008 | DOI: 10.1002/nbm.1299

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      In this study, mouse heart left ventricular remodeling was studied using diffusion tensor imaging, from 7 to 60 days after permanent ligation of the left anterior descending coronary artery. Diffusion parameters showed dynamic changes after infarction. Fractional anisotropy was higher in the infarct region, which was attributed to the development of structured collagen fibers. Nevertheless, the myofiber disarray, derived from the alignment of neighboring fibers, was higher in the infarcts.

    7. Investigation of metabolite changes in the transition from pre-invasive to invasive cervical cancer measured using 1H and 31P magic angle spinning MRS of intact tissue (pages 191–198)

      Sonali S. De Silva, Geoffrey S. Payne, Valerie Thomas, Paul G. Carter, Thomas E. J. Ind and Nandita M. deSouza

      Version of Record online: 2 OCT 2008 | DOI: 10.1002/nbm.1302

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      Metabolic changes in the transition from pre-invasive to invasive cervical cancer were investigated using high-resolution magic angle spinning magnetic resonance spectroscopy (HR-MAS MRS) in human tissue samples. Estimated concentrations of choline-containing metabolites were increased in CIN tissue from cancer patients compared to CIN tissue from non-cancer patients indicating an increase from pre-invasive to invasive cervical cancer. Concurrent metabolite depletion (alanine, creatine) was seen in normal tissue adjacent to cancer.

    8. Determination of metabolite concentrations in human brain tumour biopsy samples using HR-MAS and ERETIC measurements (pages 199–206)

      M. Carmen Martínez-Bisbal, Daniel Monleon, Olivier Assemat, Martial Piotto, José Piquer, José Luis Llácer and Bernardo Celda

      Version of Record online: 2 OCT 2008 | DOI: 10.1002/nbm.1304

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      ERETICTM (external electronically generated reference) combined with HR-MAS allows an accurate determination of metabolite concentrations in human GBM tumour biopsies. Tissue biopsy concentrations simultaneously evaluated using DSS (internal reference) were systematically higher than those determined by ERETICTM. This result indicates a possible interaction of DSS with compounds of the biopsy sample. ERETICTM metabolite concentrations matched to those determined in GBM by different in vivo, ex vivo and in vitro methodologies.

    9. You have free access to this content
      Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo1H MRS study (pages 207–212)

      N. Kickler, E. Lacombe, C. Chassain, F. Durif, A. Krainik, R. Farion, P. Provent, C. Segebarth, C. Rémy and M. Savasta

      Version of Record online: 7 JAN 2009 | DOI: 10.1002/nbm.1305

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      Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. No significant alterations in glutamate (glx) could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.

    10. A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo1H HR-MAS for childhood brain tumours (pages 213–219)

      Martin Wilson, Nigel P. Davies, Richard G. Grundy and Andrew C. Peet

      Version of Record online: 9 DEC 2008 | DOI: 10.1002/nbm.1306

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      The purpose of this study was to evaluate the agreement between the techniques of in vivo MRS and ex vivo HR-MAS for investigating childhood brain tumours. Short-TE (30 ms), single-voxel, in vivo MRS was performed on 16 paediatric patients with brain tumours at 1.5 T. A frozen biopsy sample was available for each patient. HR-MAS was performed on the biopsy samples, and metabolite quantities were determined from the MRS and HR-MAS data using the LCModelTM and TARQUIN algorithms, respectively.

    11. 1H and 31P NMR studies indicate reduced bile constituents in patients with biliary obstruction and infection (pages 220–228)

      Lakshmi Bala, Pratima Tripathi, Ganesh Bhatt, Kshaunish Das, Raja Roy, Gourdas Choudhuri and C. L. Khetrapal

      Version of Record online: 6 OCT 2008 | DOI: 10.1002/nbm.1308

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      In order to investigate a relationship between chief biliary constituents with jaundice and cholangitis, in-vitro1H and 31P NMR studies were performed on bile specimens from biliary obstructed patients (n = 80). Quantities of total bile acids, cholesterol and phosphatidylcholine correlated negatively with the quantity of bilirubin and with cholangitis, i.e. total leucocyte counts. Suppression of biliary constituents correlated significantly with the severity of jaundice and cholangitis.

    12. Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent (pages 229–239)

      Daniel Coman, Hubert K. Trubel, Robert E. Rycyna and Fahmeed Hyder

      Version of Record online: 7 JAN 2009 | DOI: 10.1002/nbm.1312

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      In the present work we demonstrate that a thulium-based macrocyclic complex, TmDOTP5−, infused through the bloodstream can be used to obtain temperature and pH maps of rat brain in vivo by 1H chemical shift imaging in conjunction with a multi-parametric model that depends on three proton resonances of the sensor. In vivo studies in α-chloralose-anesthetized and renal-ligated rats revealed temperature (33–34°C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods.

  2. Book Reviews

    1. Top of page
    2. Research Articles
    3. Book Reviews
    4. Current Awareness
  3. Current Awareness

    1. Top of page
    2. Research Articles
    3. Book Reviews
    4. Current Awareness