Metabolism of [U-13C]glucose in human brain tumors in vivo (pages 1234–1244)
Elizabeth A. Maher, Isaac Marin-Valencia, Robert M. Bachoo, Tomoyuki Mashimo, Jack Raisanen, Kimmo J. Hatanpaa, Ashish Jindal, F. Mark Jeffrey, Changho Choi, Christopher Madden, Dana Mathews, Juan M. Pascual, Bruce E. Mickey, Craig R. Malloy and Ralph J. DeBerardinis
Article first published online: 15 MAR 2012 | DOI: 10.1002/nbm.2794
Metabolic reprogramming is a hallmark of cancer cells, yet few studies have analyzed the metabolism of human tumors in vivo. Eleven patients with solitary brain tumors were infused with [U-13C]glucose during surgical resection, and metabolites extracted from the tumors were analyzed by 13C NMR spectroscopy. Primary tumors and brain metastases used glucose to supply many metabolic pathways, including glycolysis, the tricarboxylic acid cycle and amino acid synthesis.