Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination (pages 1562–1581)
Jonathan D. Thiessen, Yanbo Zhang, Handi Zhang, Lingyan Wang, Richard Buist, Marc R. Del Bigio, Jiming Kong, Xin-Min Li and Melanie Martin
Version of Record online: 13 AUG 2013 | DOI: 10.1002/nbm.2992
Cellular features in electron micrographs of the corpus callosum were correlated to several different quantitative MRI metrics. The largest Spearman correlation coefficient varied depending on cellular type: T1 versus the myelinated axon fraction (ρ = −0.90), the bound pool fraction (ƒ) versus the myelin sheath fraction (ρ = 0.93), and axial diffusivity versus the non-myelinated cell fraction (ρ = 0.92). ƒ was the strongest indicator of myelin content while longitudinal relaxation rates and diffusivity measurements were the strongest indicators of changes in tissue structure.