Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse (pages 1696–1704)
Irene Marco-Rius, Michael C. D. Tayler, Mikko I. Kettunen, Timothy J. Larkin, Kerstin N. Timm, Eva M. Serrao, Tiago B. Rodrigues, Giuseppe Pileio, Jan Henrik Ardenkjaer-Larsen, Malcolm H. Levitt and Kevin M. Brindle
Article first published online: 15 AUG 2013 | DOI: 10.1002/nbm.3005
The 13C singlet lifetime of [1,2-13C2]pyruvate is significantly longer than the 13C T1 in human blood and in a mouse in vivo at millitesla fields. The singlet-derived NMR spectrum observed for hyperpolarized [1,2-13C2]lactate, originating from the metabolism of [1,2-13C2]pyruvate, is also examined.