Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: a 1H MRS study (pages 204–212)
Jing Qi, Yuman Fong, Leonard Saltz, Michael I. D'Angelica, Nancy E. Kemeny, Mithat Gonen, Jinru Shia, Amita Shukla-Dave, William M. Jarnagin, Richard K. G. Do, Lawrence H. Schwartz, Jason A. Koutcher and Kristen L. Zakian
Version of Record online: 7 SEP 2012 | DOI: 10.1002/nbm.2837
Hepatic lipids were measured by localized 1H MRS over a period of 24 weeks in patients with colorectal cancer being treated with chemotherapy. Lipid levels increased in 13 of 26 patients and six converted from nonsteatotic to steatotic. An elevation in lipids at 6 weeks predicted that a patient would complete chemotherapy at 24 weeks with hepatic lipids significantly increased relative to the baseline level.