Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T (pages 1656–1665)
Petra Hnilicová, Michal Považan, Bernhard Strasser, Ovidiu C. Andronesi, Martin Gajdošík, Ulrike Dydak, Jozef Ukropec, Dušan Dobrota, Siegfried Trattnig and Wolfgang Bogner
Version of Record online: 7 OCT 2016 | DOI: 10.1002/nbm.3613
A spiral-encoding MEGA-LASER 3D-MRSI sequence was applied with real-time artifact correction to acquire GABA-edited MR spectra of healthy brains at 3 T. A nominal resolution of about 3 cm3 was achieved in about 20 min and a low inter- and intra-subject variability for this method was confirmed. This fast and robust method for 3D mapping of GABA+ and Glx may be used in studies that investigate neurotransmitter alterations in the brain. 3D metabolic maps of GABA+ obtained by GABA-edited MEGA-LASER 3D-MRSI in three orthogonal planes, along with T1-weighted MR images.