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Nicotinic receptor-mediated effects on appetite and food intake

  1. Young-Hwan Jo1,
  2. David A. Talmage2,
  3. Lorna W. Role1,*

Article first published online: 15 NOV 2002

DOI: 10.1002/neu.10147

Issue

Journal of Neurobiology

Journal of Neurobiology

Special Issue: Nicotinic Signaling

Volume 53, Issue 4, pages 618–632, December 2002

Additional Information

How to Cite

Jo, Y.-H., Talmage, D. A. and Role, L. W. (2002), Nicotinic receptor-mediated effects on appetite and food intake. J. Neurobiol., 53: 618–632. doi: 10.1002/neu.10147

Author Information

  1. 1

    Department of Anatomy and Cell Biology, in the Center for Neurobiology and Behavior

  2. 2

    Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY 10032

*Department of Anatomy and Cell Biology, in the Center for Neurobiology and Behavior and the Institute of Human Nutrition, Columbia University, College of Physicians and Surgeons, New York, NY 10032

Publication History

  1. Issue published online: 15 NOV 2002
  2. Article first published online: 15 NOV 2002
  3. Manuscript Accepted: 31 JUL 2002
  4. Manuscript Received: 2 JUL 2002

Funded by

  • National Institutes of Health. Grant Numbers: NS29071, NS22061, CA79737

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Keywords:

  • orexin;
  • M-H;
  • lateral hypothalamus;
  • acetylcholine

Abstract

It is well known, although not well understood, that smoking and eating just do not go together. Smoking is associated with decreased food intake and lower body weight. Nicotine, administered either by smoking or by smokeless routes, is considered the major appetite-suppressing component of tobacco. Perhaps the most renowned example of nicotine's influence on appetite and feeding behavior is the significant weight gain associated with smoking cessation. This article presents an overview of the literature at, or near, the interface of nicotinic receptors and appetite regulation. We first consider some of the possible sites of nicotine's action along the complex network of neural and non-neural regulators of feeding. We then present the hypothesis that the lateral hypothalamus is a particularly important locus of the anorectic effects of nicotine. Finally, we discuss the potential role of endogenous cholinergic systems in motivational feeding, focusing on cholinergic pathways in the lateral hypothalamus. © 2002 Wiley Periodicals, Inc. J Neurobiol 53: 618–632, 2002

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