ERK/MAPK pathway regulates GABAA receptors
Article first published online: 29 SEP 2006
Copyright © 2006 Wiley Periodicals, Inc.
Journal of Neurobiology
Volume 66, Issue 13, pages 1467–1474, November 2006
How to Cite
Bell-Horner, C. L., Dohi, A., Nguyen, Q., Dillon, G. H. and Singh, M. (2006), ERK/MAPK pathway regulates GABAA receptors. J. Neurobiol., 66: 1467–1474. doi: 10.1002/neu.20327
- Issue published online: 18 OCT 2006
- Article first published online: 29 SEP 2006
- Manuscript Accepted: 7 JUL 2006
- Manuscript Revised: 5 JUL 2006
- Manuscript Received: 27 FEB 2006
- NIH. Grant Numbers: AG23330, AG22550, ES07904
- 2002. Molecular psychology: Roles for the ERK MAP kinase cascade in memory. Annu Rev Pharmacol Toxicol 42: 135–163. , .
- 2001. GABAA receptor subunit interactions important for benzodiazepine and zinc modulation: A patch-clamp and single cell RT-PCR study. Eur J Neurosci 13: 1673–1682. , , , , .
- 2002. Multiple roles of protein kinases in the modulation of γ-aminobutyric acid(A) receptor function and cell surface expression. Pharmacol Ther 94: 113–122. , , .
- 1990. Protein kinase C and cAMP-dependent protein kinase phosphorylate the β subunit of the purified γ-aminobutyric acid A receptor. Proc Natl Acad Sci USA 87: 1315–1318. , , , .
- 1996. Stoichiometry of a recombinant GABAA receptor. J Neurosci 16: 5415–5424. , , , .
- 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745–2752. , .
- 1998. Modulation of GABAergic receptor binding by activation of calcium and calmodulin-dependent kinase II membrane phosphorylation. Brain Res 809: 68–76. , .
- 2002. Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor α1 subunit modulates benzodiazepine binding. J Neurochem 82: 1065–1076. , , , , , .
- 1996. Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival. J Biol Chem 271: 20713–20718. , , .
- 1995. Transcriptional regulation by MAP kinases. Mol Reprod Dev 42: 459–467. .
- 1998. Inhibition of GABAA receptor function by tyrosine kinase inhibitors and their inactive analogues. Mol Cell Neurosci 12: 300–310. , , .
- 1993. Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line. Neurosci Lett 153: 206–209. , , , , , .
- 2005. PKC modulation of GABAA receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β 2 subunit. Neuropharmacology 48: 181–194. , , , , .
- 2003. Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β 2 subunit of the receptor. J Biol Chem 278: 24046–24052. , , , , , .
- 2001. Pentylenetetrazole-induced inhibition of recombinant GABAA receptors: Mechanism and site of action. J Pharmacol Exp Ther 298: 986–995. , , , , , .
- 1998. Maintenance of recombinant type A γ-aminobutyric acid receptor function: Role of protein tyrosine phosphorylation and calcineurin. J Pharmacol Exp Ther 286: 243–255. , .
- 1999. Effect of extracellular pH on GABA-activated current in rat recombinant receptors and thin hypothalamic slices. J Neurophysiol 82: 1233–1243. , .
- 1999. The tyrosine kinase inhibitor genistein directly inhibits GABAA receptors. Brain Res Mol Brain Res 67: 177–183. , , .
- 1996. Cyclic AMP-dependent protein kinase enhances hippocampal dentate granule cell GABAA receptor currents. J Neurophysiol 76: 2626–2634. , .
- 1989. Phosphorylation of γ-aminobutyrate (GABA)/benzodiazepine receptors by cyclic AMP-dependent protein kinase. Biochem J 259: 613–616. , , , .
- 1999. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene 18: 2055–2068. , , , .
- 1996. Enhancement of recombinant α 1 β 1 γ 2L γ-aminobutyric acid A receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both β 1 and γ 2L subunits. Mol Pharmacol 50: 185–195. , , , , .
- 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275. , , , .
- 1994. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 4: 82–89. .
- 1998. Adjacent phosphorylation sites on GABAA receptor β subunits determine regulation by cAMP-dependent protein kinase. Nat Neurosci 1: 23–28. , , , , , .
- 1994. Differential phosphorylation of intracellular domains of γ-aminobutyric acid type A receptor subunits by calcium/calmodulin type 2-dependent protein kinase and cGMP-dependent protein kinase. J Biol Chem 269: 18111–18117. , .
- 1997. Conserved phosphorylation of the intracellular domains of GABA(A) receptor β2 and β3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase protein kinase C and Ca2+/calmodulin type II-dependent protein kinase. Neuropharmacology 36: 1377–1385. , .
- 1992. Identification of the cAMP-dependent protein kinase and protein kinase C phosphorylation sites within the major intracellular domains of the β 1, γ 2S, and γ 2L subunits of the γ-aminobutyric acid type A receptor. J Biol Chem 267: 14470–14476. , , .
- 1995. Modulation of GABAA receptors by tyrosine phosphorylation. Nature 377: 344–348. , , , .
- 1996. Modulation of amino acid-gated ion channels by protein phosphorylation. Int Rev Neurobiol 39: 1–52. , .
- 1999. Ion channels as physiological effectors for growth factor receptor and Ras/ERK signaling pathways. Adv Second Messenger Phosphoprotein Res 33: 107–127. .
- 2006. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290: C852–C861. , , , , , , .
- 1995. The MAPK signaling cascade. FASEB J 9: 726–735. , .
- 1998. Extracellular signal-regulated kinase (ERK) controls immediate early gene induction on corticostriatal stimulation. J Neurosci 18: 8814–8825. , , , , .
- 1996. Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci Lett 212: 13–16. , , , .
- 1999. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways. J Neurosci 19: 1179–1188. , , , , .
- 1996. Gene activation pathways of nerve growth factor signaling: A minireview. Neurobiology (Bp) 4: 1–11. .
- 1994. Cellular components of nerve growth factor signaling. Biochim Biophys Acta 1222: 187–202. , .
- 2001. Extracellular signal-regulated kinase, synaptic plasticity, and memory. Rev Neurosci 12: 327–345. , .
- 1995. Tyrosine kinase phosphorylation of GABAA receptors. Brain Res Mol Brain Res 31: 165–172. , , , , , , , et al.
- 1999. Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Mol Cell Biol 19: 136–146. , , , , , , .
- 1998. Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. J Neurosci 18: 2342–2349. , , .
- 1995. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403–407. , , , .
- 1992. GABAA receptor channels: From subunits to functional entities. Curr Opin Neurobiol 2: 263–269. , .
- 1998. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. Mol Cell Biol 18: 1946–1955. , , , , .
- 1998. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci 18: 4042–4049. , .