Excitotoxic cell death
Article first published online: 11 OCT 2004
Copyright © 1992 John Wiley & Sons, Inc.
Journal of Neurobiology
Volume 23, Issue 9, pages 1261–1276, November 1992
How to Cite
Choi, D. W. (1992), Excitotoxic cell death. J. Neurobiol., 23: 1261–1276. doi: 10.1002/neu.480230915
- Issue published online: 11 OCT 2004
- Article first published online: 11 OCT 2004
- Manuscript Accepted: 24 JUN 1992
- Manuscript Received: 6 JUN 1992
- cell culture
Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states. Excitotoxicity has substantial cellular specificity and, in most cases, is mediated by glutamate receptors. On average, NMDA receptors activation may be able to trigger lethal injury more rapidly than AMPA or kainate receptor activation, perhaps reflecting a greater ability to induce calcium influx and subsequent cellular calcium overload. It is possible that excitotoxic death may share some mechanisms with other forms of neuronal death. © 1992 John Wiley & Sons, Inc.