Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans

Authors

  • Kwok-Ming Yao,

    1. Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
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  • Marie-Laure Samson,

    1. Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
    2. Waksman Institute, Rutgers University, Piscataway, New Jersey 08855
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  • Ronald Reeves,

    1. Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
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  • Kalpana White

    Corresponding author
    1. Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
    • Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254
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Abstract

Regulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation. © 1993 John Wiley & Sons, Inc.

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