PhD, RN, Clinical Associate Professor.
Effects of antenatal magnesium sulfate and corticosteroid therapy on sleep states of preterm infants†
Article first published online: 17 JUL 2006
Copyright © 2006 Wiley-Liss, Inc.
Research in Nursing & Health
Volume 29, Issue 4, pages 269–280, August 2006
How to Cite
Black, B., Holditch-Davis, D., Schwartz, T. and Scher, M. S. (2006), Effects of antenatal magnesium sulfate and corticosteroid therapy on sleep states of preterm infants. Res. Nurs. Health, 29: 269–280. doi: 10.1002/nur.20141
We wish to thank Sola Park, Lisa Moorehead, Mary Barkey, Diane Hudson-Barr, Donna Harris, Tzu-Ying Lee, Leslie Miller, Jeanmarie Kanegan, Dawn Salerno, Tanya Kewson, Jason Dickenson, and Mark Johnson for technical assistance.
- Issue published online: 17 JUL 2006
- Article first published online: 17 JUL 2006
- Manuscript Accepted: 4 JAN 2006
- National Institutes of Health National Institute of Nursing Research. Grant Number: NR01894
- magnesium sulfate;
- preterm infants
This exploratory longitudinal study was designed to compare the neonatal illness severity, sleep–wake, and respiratory sleep behaviors of preterm infants whose mothers received prenatal corticosteroids and/or magnesium sulfate (MgSO4) with those of infants whose mothers did not receive these medications. The 134 infants were divided into four groups: those whose mothers received MgSO4 only, those who received steroids only, those who received both MgSO4 and steroids, and those who received neither. The groups did not differ on infant characteristics or illness severity. Infants exposed to MgSO4 had more active sleep without rapid eye movement, indicating poorly organized active sleep. The MgSO4-only group had higher quiet sleep regularity scores and fewer state changes. These findings suggest that fetal exposure to MgSO4 may subtly affect the central nervous system. © 2006 Wiley Periodicals, Inc. Res Nurs Health 29: 269–280, 2006