High-density lipoprotein prevents organ damage in endotoxemia†
Article first published online: 18 MAY 2007
Copyright © 2007 Wiley Periodicals, Inc.
Research in Nursing & Health
Volume 30, Issue 3, pages 250–260, June 2007
How to Cite
Lee, R.-P., Lin, N.-T., Chao, Y.-F. C., Lin, C.-C., Harn, H.-J. and Chen, H.-I. (2007), High-density lipoprotein prevents organ damage in endotoxemia. Res. Nurs. Health, 30: 250–260. doi: 10.1002/nur.20187
We thank Mike Biological Technique Company for technical advice.
- Issue published online: 18 MAY 2007
- Article first published online: 18 MAY 2007
- Manuscript Accepted: 20 NOV 2006
- Tzu Chi Foundation. Grant Number: TCMRC-902005
- animal model;
- organ damage
High-density lipoprotein (HDL) may decrease organ injury in sepsis. This study was designed using an animal model to mimic people who had a high HDL level and to test HDL effects on preventing organ damage in endotoxemia. Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration. Levels of blood biochemical substances, nitrate/nitrite, and TNF-α in sera were measured. Pathological examinations were performed 72 hours after LPS infusion. HDL decreased the endotoxin-induced elevation of AST, ALT, BUN, creatinine, LDH, CPK, nitrate/nitrite, and TNF-α. On histological examination, neutrophil infiltration was lower in the HDL group. HDL had a significant effect in preventing endotoxin-induced organ damage. © 2007 Wiley Periodicals, Inc. Res Nurs Health 30: 250–260, 2007