The purpose of this study was to determine the association between selected social cognitive variables and self-management behaviors among a sample of adults with epilepsy. The study, based on Social Cognitive Theory, was a partial replication and extension of a previous study that explored the role of self-efficacy and social support in epilepsy self-management. The variables examined in the present study were self-efficacy, social support, regimen-specific support, self-esteem, and self-management. Data collected from 80 adults attending an epilepsy clinic were analyzed using correlation and regression procedures. Statistically significant relationships were found between self-efficacy and self-management and between regimen-specific support and self-management. Regression analyses revealed that self-efficacy and regimen-specific support made significant contributions to the variance in self-management, whereas social support and self-esteem did not.