Disclosure: The authors declared no conflict of interest.
Article first published online: 26 MAR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 2, pages 291–296, February 2013
How to Cite
Chiang, C.-H., Lai, J.-S., Hung, S.-H., Lee, L.-T., Sheu, J.-C. and Huang, K.-C. (2013), Serum adiponectin levels are associated with hepatitis B viral load in overweight to obese hepatitis B virus carriers. Obesity, 21: 291–296. doi: 10.1002/oby.20000
Funding agencies: This study was sponsored by the research fund of National Taiwan University (NTU 98R0537-01) and National Health Research Institutes (98A1-PHPP51-014).
- Issue published online: 26 MAR 2013
- Article first published online: 26 MAR 2013
- Accepted manuscript online: 7 AUG 2012 02:42PM EST
- Manuscript Accepted: 31 MAY 2012
- Manuscript Received: 9 NOV 2011
This study aimed to investigate the association between serum adiponectin and chronic hepatitis B virus (HBV) infection.
Design and Methods:
We conducted a campus-based cross-sectional study in Northern Taiwan, an HBV-endemic country. A total of 506 participants, including 147 chronic HBV-infected individuals and 359 healthy controls, were assessed for anthropometric indices, serum adiponectin levels, serum HBV viral load and markers, serum alanine aminotransferase levels and metabolic factors.
Older age, male gender, higher alanine aminotransferase, higher body mass index, greater waist circumference, lower fasting glucose, higher triglycerides, and higher adiponectin were associated with chronic HBV infection in univariate analyses. In multivariate analysis, the presence of chronic HBV infection was positively associated with serum adiponectin levels (P < 0.0001) and high adiponectin levels over the 75th percentile (odds ratio, 4.25; 95% confidence interval, 2.36-7.66; P < 0.0001) after adjusting for age, gender, body mass index, and insulin resistance index. Furthermore, serum adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects (P = 0.018).
Although chronic HBV-infected individuals were heavier than healthy controls, they had significantly higher serum adiponectin levels than healthy counterparts. Additionally, adiponectin levels were positively associated with HBV viral load in overweight to obese HBV-infected subjects. Future research should focus on elucidating adiponectin pathways, which may contribute to the development of adjuvant treatments for chronic HBV infection.