Disclosure: The authors declared no conflict of interest.
Article first published online: 16 APR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 3, pages 602–608, March 2013
How to Cite
Smith, C. E., Tucker, K. L., Lee, Y.-C., Lai, C.-Q., Parnell, L. D. and Ordovás, J. M. (2013), Low-density lipoprotein receptor-related protein 1 variant interacts with saturated fatty acids in puerto ricans. Obesity, 21: 602–608. doi: 10.1002/oby.20001
Funding agencies: Supported by the National Institutes of Health, National Institute on Aging, grant number 5P01AG023394-02 and NIH/NHLBI grant number HL54776 and NIH/NIDDK DK075030 and contracts 53-K06-5-10 and 58-1950-9-001 from the US Department of Agriculture Research Service.
- Issue published online: 16 APR 2013
- Article first published online: 16 APR 2013
- Accepted manuscript online: 7 AUG 2012 02:42PM EST
- Manuscript Accepted: 31 MAY 2012
- Manuscript Received: 24 JAN 2012
- National Institutes of Health, National Institute on Aging. Grant Number: 5P01AG023394-02
- NIH/NHLBI. Grant Numbers: HL54776, NIH/NIDDK DK075030, 53-K06-5-10, 58-1950-9-001
- US Department of Agriculture Research Service
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional endocytic receptor that is highly expressed in adipocytes and the hypothalamus. Animal models and in vitro studies support a role for LRP1 in adipocyte metabolism and leptin signaling, but genetic polymorphisms have not been evaluated for obesity in people.
Design and Methods:
We examined whether dietary fats (eg., saturated, polyunsaturated) modulated the association of LRP1 rs1799986 with anthropometric traits. We studied a population-based sample of Puerto Ricans (n = 920, aged 45–74 y) living in the Boston area.We examined whether dietary fats (eg., saturated, polyunsaturated) modulated the association of LRP1 rs1799986 with anthropometric traits. We studied a population-based sample of Puerto Ricans (n = 920, aged 45–74 y) living in the Boston area.
In multivariable linear regression models, we dichotomized saturated fat intake and found significant interaction terms between total saturated fatty acids and LRP1 rs1799986 genotype for BMI (P=0.006) and hip (P = 0.002). High intake of saturated fat was associated with higher BMI (P = 0.001), waist (P = 0.008) and hip (P=0.003) in minor allele carriers (CT+TT) compared to CC participants. Further analysis of dichotomized individual saturated fatty acids revealed that interactions were strongest for two individual longer chain fatty acids. High intake of palmitic acid (C16:0; P = 0.0007) and high stearic acid intake (C18:0; P = 0.005) were associated with higher BMI in T carriers. Interactions were not detected for polyunsaturated fatty acids.
Gene–diet interactions at the LRP1 locus support the hypothesis that susceptibility to weight gain based on saturated fatty acids is modified by genotype and possibly by chain length. These results may facilitate the development of a panel of genetic candidates for use in optimizing dietary recommendations for obesity management.