Disclosure: The authors declared no conflict of interest.
Article first published online: 16 APR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 3, pages E294–E302, March 2013
How to Cite
Vinknes, K. J., Elshorbagy, A. K., Nurk, E., Drevon, C. A., Gjesdal, C. G., Tell, G. S., Nygård, O., Vollset, S. E. and Refsum, H. (2013), Plasma stearoyl-CoA desaturase indices: Association with lifestyle, diet, and body composition. Obesity, 21: E294–E302. doi: 10.1002/oby.20011
Funding Agencies: This study has received support from the Advanced Research Programme of Norway, The Research Council of Norway, Norwegian Rheumatism Association, The Johan Throne Holst Foundation for Nutrition Research, and University of Oslo, Norway.
- Issue published online: 16 APR 2013
- Article first published online: 16 APR 2013
- Accepted manuscript online: 15 AUG 2012 10:29AM EST
- Manuscript Accepted: 4 JUN 2012
- Manuscript Received: 19 JAN 2012
Stearoyl-coenzyme A desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism. Increased hepatic SCD1 activity is associated with obesity and obesity-related diseases. We examined the relations of two plasma SCD activity indices (16:1n-7/16:0, 18:1n-9/18:0) with body composition, and the association of lifestyle and dietary variables with the plasma SCD indices.
Design and Methods:
This population-based, cross-sectional study of 2021 elderly (71–74 y) men and women from the Hordaland Health Study in Western Norway was conducted using a validated food frequency questionnaire, body composition measurements by dual-energy X-ray absorptiometry and determination of the plasma fatty acid profile.
In multivariate regression analyses, plasma SCD indices were positively associated with BMI and body fat (P < 0.001 for both). From the 2.5th to 97.5th percentiles of plasma SCD-16 and SCD-18 indices, fat mass differed by about 8 kg and 5 kg, respectively. Intake of polyunsaturated fatty acids were negatively associated with SCD-16 (partial r = −0.30) and SCD-18 (partial r = −0.24) (P < 0.001 for both). Alcohol intake was positively associated with SCD-16 (partial r = 0.26) and SCD-18 (partial r = 0.16) (P < 0.001 for both), whereas coffee consumption and physical activity were inversely associated with SCD-16 (P = 0.026 and P = 0.006, respectively) and SCD-18 (P = 0.001 and P = 0.022, respectively).
In this elderly population, plasma markers of SCD1 activity are associated with increased adiposity. Furthermore, modifiable dietary habits and lifestyle are associated with plasma SCD indices. These results suggest that SCD1 activity may be a promising target for weight control.