Disclosure: The authors declared no conflict of interest.
Development of metabolic syndrome components in adults with a healthy obese phenotype: A 3-year follow-up†
Version of Record online: 9 APR 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 5, pages 1025–1030, May 2013
How to Cite
Engelsen, C. d., Gorter, K.J., Salomé, P.L. and Rutten, G.E. (2013), Development of metabolic syndrome components in adults with a healthy obese phenotype: A 3-year follow-up. Obesity, 21: 1025–1030. doi: 10.1002/oby.20049
- Issue online: 20 JUN 2013
- Version of Record online: 9 APR 2013
- Accepted manuscript online: 3 OCT 2012 08:07AM EST
- Manuscript Accepted: 14 AUG 2012
- Manuscript Received: 27 DEC 2011
- Investigator Initiated Studies Program of Merck Sharp & Dome Corp
- Merck Sharp & Dome Corp
There is a lack of data on the progression from a healthy obese phenotype toward an unhealthy obese phenotype and the development of metabolic syndrome (MetS). Our aim was to assess the development of MetS 3 years after screening in centrally obese individuals with a healthy obese phenotype and to evaluate the usefulness of repeated screening.
Design and Methods:
Eighty-eight individuals (mean age 47 years, 88% female) with central obesity as their only MetS component (ATP III criteria) at baseline screening were re-evaluated for MetS status after 3 years.
At follow-up, the cardiometabolic risk profile in centrally obese individuals with a healthy phenotype showed a tendency toward deterioration. Thirty-two percent developed at least one additional MetS component, 7% had developed MetS. Nobody had developed type 2 diabetes. An increased triglyceride level (n = 16) and an increased blood pressure (n = 18) were the components most often present at follow-up. The people developing additional MetS components had a lower education level compared with the group that preserved the healthy centrally obese phenotype (80 vs. 71% lower educated, P = 0.35). They also had slightly worse baseline levels of the risk factors.
The number of centrally obese individuals developing an unhealthy phenotype in this relatively short follow-up period emphasizes the need for a regular surveillance of cardiometabolic parameters in centrally obese individuals. However, it is questionable whether a repeated screening for type 2 diabetes every 3 years, as recommended by the American Diabetes Association, in this category of patients is appropriate.