Disclosure: The authors declared no conflict of interest.
High protein intake stimulates postprandial GLP1 and PYY release
Version of Record online: 13 MAY 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 8, pages 1602–1607, August 2013
How to Cite
van der Klaauw, A. A., Keogh, J. M., Henning, E., Trowse, V. M., Dhillo, W. S., Ghatei, M. A. and Farooqi, I. S. (2013), High protein intake stimulates postprandial GLP1 and PYY release. Obesity, 21: 1602–1607. doi: 10.1002/oby.20154
Funding agencies: This work was supported by The Wellcome Trust, MRC Center for Obesity and Related Metabolic Disease and the National Institute of Health Research Cambridge Biomedical Research Center and the Bernard Wolfe Health Neuroscience Fund.
- Issue online: 22 AUG 2013
- Version of Record online: 13 MAY 2013
- Accepted manuscript online: 6 NOV 2012 08:13AM EST
- Manuscript Accepted: 24 OCT 2012
- Manuscript Received: 10 NOV 2011
- The Wellcome Trust
- MRC Center for Obesity
- Related Metabolic Disease
- National Institute of Health Research Cambridge Biomedical Research Center
- Bernard Wolfe Health Neuroscience Fund
Meals high in protein induce greater intermeal satiety than meals high in fat and carbohydrates. We studied the gut hormone response and subsequent food intake after breakfasts high in protein, carbohydrate or high in fat controlled for volume, calories and appearance.
Design and Methods
Eight healthy volunteers participated in this randomized three-way crossover study. Study breakfasts were calculated to provide 20% of daily energy requirements and provided either 60% of energy from protein, fat or carbohydrate. Blood was drawn half-hourly for 4 h; energy intake at a subsequent ad libitum meal was measured.
Total ghrelin decreased after food intake equally with the three breakfasts. PYY levels were highest after the high protein breakfast (P = 0.005). Indeed, PYY at 240 min was highest after the high protein breakfast compared to the high fat breakfast and to the high carbohydrate breakfast (P = 0.011 and P = 0.012, respectively). GLP-1 levels were highest after the high protein breakfast (P = 0.041) at 120 min and remained higher throughout the study. These differences in gut hormones did not translate into differences in food intake (1023 ± 390 kcal after high protein, 1016 ± 388 kcal after high fat and 1158 ± 433 kcal after high carbohydrate).
We conclude that a high protein meal increases circulating concentrations of the gut hormones PYY and GLP-1, but when meals are matched for volume, appearance and caloric value, these gut hormone changes do not translate into a reduction in ad libitum food intake.