Funding agencies: This study was supported by the National Heart, Lung and Blood Institute's Framingham Heart Study (contract N01-HC-25195), and by RO1 HL70100; 1ROI HL60040); HL077447;K12 HL083786.
Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function
Article first published online: 11 JUN 2013
Copyright © 2013 The Obesity Society
Volume 21, Issue 7, pages 1496–1503, July 2013
How to Cite
Britton, K. A., Wang, N., Palmisano, J., Corsini, E., Schlett, C. L., Hoffmann, U., Larson, M. G., Vasan, R. S., Vita, J. A., Mitchell, G. F., Benjamin, E. J., Hamburg, N. M. and Fox, C. S. (2013), Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function. Obesity, 21: 1496–1503. doi: 10.1002/oby.20166
- Issue published online: 12 AUG 2013
- Article first published online: 11 JUN 2013
- Accepted manuscript online: 29 NOV 2012 04:10PM EST
- Manuscript Accepted: 3 NOV 2012
- Manuscript Received: 17 APR 2012
Objective: Perivascular fat may have a local adverse effect on the vasculature. We evaluated whether thoracic periaortic adipose tissue (TAT), a type of perivascular fat, and visceral adipose tissue (VAT) were associated with vascular function.
Design and Methods
TAT and VAT were quantified in Framingham Heart Study participants using multidetector-computed tomography; vascular function was assessed using brachial artery vasodilator function, peripheral arterial tone, and arterial tonometry (n = 2,735; 48% women; mean age, 50 years; mean body mass index [BMI], 27.7 kg/m2). Using multiple linear regression, the relationships between TAT, VAT, and vascular measures was examined while adjusting for cardiovascular risk factors.
Mean TAT and VAT volumes were 13.2 and 1763 cm3. TAT and VAT were associated with multiple vascular function measures after multivariable adjustment. After BMI adjustment, TAT and VAT remained negatively associated with peripheral arterial tone and inverse carotid femoral pulse wave velocity (P < 0.02); TAT was negatively associated with hyperemic mean flow velocity (P = 0.03). Associations of TAT with vascular function were attenuated after VAT adjustment (all P > 0.06).
Thoracic periaortic and visceral fat are associated with microvascular function and large artery stiffness after BMI adjustment. These findings support the growing recognition of associations between ectopic fat and vascular function.