Disclosure: Authors of this study have no interest which might be perceived as posing a conflict or bias.
Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress
Version of Record online: 13 MAY 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 8, pages 1613–1617, August 2013
How to Cite
Celik, S., Tangi, F., Kilicaslan, E., Sanisoglu, Y. S., Oktenli, C. and Top, C. (2013), Increased acylation stimulating protein levels in young obese males is correlated with systemic markers of oxidative stress. Obesity, 21: 1613–1617. doi: 10.1002/oby.20175
- Issue online: 22 AUG 2013
- Version of Record online: 13 MAY 2013
- Accepted manuscript online: 30 NOV 2012 09:02AM EST
- Manuscript Accepted: 4 NOV 2012
- Manuscript Received: 2 MAR 2012
As little is known about relationship between acylation stimulating protein (ASP) and oxidative stress, whether there is any link between ASP and oxidative stress in young obese males were investigated.
Design and Methods
Forty-five obese (median body mass index (BMI) = 36.99 (IQR = 3.65) kg m−2) male subjects (median age = 22 (IQR = 6) years) and 24 age-matched (median age = 22.5 (IQR = 4.8) years) healthy male volunteers (median body mass index (BMI) = 23.67 (IQR = 2.45) kg m−2) were recruited into the study. All obese subjects have BMI > 30 kg m−2, while all controls have BMI < 25 kg m−2.
Fasting plasma ASP, lipid hydroperoxide, high sensitivity C-reactive protein (hs-CRP), fasting insulin, triglyceride, LDL-cholesterol levels and HOMA-IR were higher, whereas the mean HDL-cholesterol levels and glutathione peroxidase (GPx) enzyme activity were significantly lower in obese subjects than controls. The linear regression analysis showed that lipid hydroperoxide was independently associated with only BMI, while ASP was independently associated with BMI and triglyceride.
The present data support the concept that obesity occurs under condition of compex interactions by adipokines, insulin, inflammation, and oxidative stress.