Partial sleep deprivation by environmental noise increases food intake and body weight in obesity-resistant rats

Authors

  • Vijayakumar Mavanji,

    1. Minnesota Obesity Prevention Training Program, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
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    • Disclosure: The authors declared no conflict of interest.

  • Jennifer A. Teske,

    1. Department of Nutritional Sciences, University of Arizona, Tucson, Arizona, USA
    2. Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona, USA
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  • Charles J. Billington,

    1. Minnesota Obesity Prevention Training Program, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    2. Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    3. Minnesota Obesity Center, Minneapolis, Minnesota, USA
    4. Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
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  • Catherine M. Kotz

    1. Minnesota Obesity Prevention Training Program, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    2. Veterans Affairs Medical Center, Minneapolis, Minnesota, USA
    3. Minnesota Obesity Center, Minneapolis, Minnesota, USA
    4. Department of Food Science and Nutrition, University of Minnesota, Saint Paul, Minnesota, USA
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  • Funding agencies: Funding for this publication was provided by the Department of Veterans Affairs; NIH R01DK078985 (to CMK), NIH P30 DK050456 (to CJB), and NIH T32DK083250 (to CJB, CMK and VM) from the National Institute of Diabetes and Digestive and Kidney Diseases and a grant from the Obesity Society (to JAT).

Correspondence: Vijayakumar Mavanji (mavan001@umn.edu)

Abstract

Objective

Sleep restriction in humans increases risk for obesity, but previous rodent studies show weight loss following sleep deprivation, possibly due to stressful methods used to prevent sleep. Obesity-resistant (OR) rats exhibit consolidated-sleep and resistance to weight gain. It was hypothesized that sleep disruption by a less-stressful method would increase body weight, and the effect of partial sleep deprivation (PSD) on body weight in OR and Sprague-Dawley (SD) rats was examined.

Design and Methods

OR and SD rats (n = 12/group) were implanted with transmitters to record sleep/wake. After baseline recording, six SD and six OR rats underwent 8 h PSD during light phase for 9 days. Sleep was reduced using recordings of random noise. Sleep/wake states were scored as wakefulness (W), slow-wave-sleep (SWS), and rapid-eye-movement-sleep (REMS). Total number of transitions between stages, SWS-delta-power, food intake, and body weight were documented.

Results

Exposure to noise decreased SWS and REMS time, while increasing W time. Sleep-deprivation increased the number of transitions between stages and SWS-delta-power. Further, PSD during the rest phase increased recovery sleep during the active phase. The PSD SD and OR rats had greater food intake and body weight compared to controls

Conclusions

PSD by less-stressful means increases body weight in rats. Also, PSD during the rest phase increases active period sleep.

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