Disclosure: The authors declared no conflicts of interest.
Interactions of genetic and environmental risk factors with respect to body fat mass in children: Results from the ALSPAC study
Version of Record online: 13 MAY 2013
Copyright © 2012 The Obesity Society
Volume 21, Issue 6, pages 1238–1242, June 2013
How to Cite
Riedel, C., von Kries, R., Fenske, N., Strauch, K., Ness, A. R. and Beyerlein, A. (2013), Interactions of genetic and environmental risk factors with respect to body fat mass in children: Results from the ALSPAC study. Obesity, 21: 1238–1242. doi: 10.1002/oby.20196
Funding agencies: This work was supported by the Deutsche Forschungsgemeinschaft (project BE 4682/1-1).
- Issue online: 26 JUL 2013
- Version of Record online: 13 MAY 2013
- Accepted manuscript online: 30 NOV 2012 08:59AM EST
- Manuscript Accepted: 13 NOV 2012
- Manuscript Received: 23 AUG 2012
To evaluate if percentile-specific effects of genetic, environmental and lifestyle obesity risk factors on body mass index (BMI) might reflect gene-environment interactions with respect to the development of overweight.
Design and Methods
Retrospective study with data of 2,346 children from the Avon Longitudinal Study of Parents and Children (ALSPAC), using quantile regression with body fat mass index (FMI) for children at the age of 9 years as outcome variable. We assessed interactions of an “obesity-risk-allele-score” with environmental and nutritional factors.
There was no evidence of interactions between the obesity-risk-allele score and the environmental variables except for maternal overweight. However, we found a significant interaction with respect to intake of mono- and polyunsaturated fatty acids at the age of 7. In children with low intake, genetic risk was associated with increasing effect sizes by FMI percentile.
Our results suggest an interaction between a low dietary content of unsaturated fatty acids and genetic risk factors for overweight on FMI. This effect is likely to be stronger in children with higher FMI.